Patients with mild to moderate plaque type psoriasis who willing to apply CanPatch Cannabis Psoriasis Microbiota Cannabidiol
Conditions
Interventions
The participants will be instructed to apply CBD/minimal THC patch (CanPatch) on the same selected lesion everyday for 90 days and at least 6 hours a day,The participants will be instructed to apply p
Experimental Drug,Placebo Comparator Drug
Group 1,Group 2
Sponsors
Thai Traditional Medical Knowledge Fund
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. More than 18 years old 2. Has been diagnosed with mild to moderate plaque type psoriasis with baseline PASI score less than 10 by a board-certified dermatologist 3. Have two or more psoriasis plaque of comparable size and severity 4. Abstain from topical treatment for psoriasis more than 2 weeks prior to the research 5. Could completely contemplate Thai language 6. Have ability and willingness to sign inform-consent form for the research
Exclusion criteria
Exclusion criteria: 1. Pregnant women or women who are currently breastfed. 2. Contraindication to cannabis transdermal patch (Allergy to products of CanPatch or have history of severe cardiovascular disease, liver disease, renal disease and serious psychiatric disease) 3. Addictive behavior or previously defined as abuse of cannabis (Determined through patient interview and medical records) 4. Receive biologics therapy for psoriasis treatments 5. Patients who have had less than 12 weeks of systemic conventional therapy for psoriasis (oral medications or phototherapy) 6. Patients who have been receiving systemic conventional therapy for psoriasis (oral medications or phototherapy) for more than 12 weeks, but who have seen variations in psoriasis symptoms or adjustments to their medication or phototherapy regimen within the past 12 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy 3 month Local Psoriasis Severity Index | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy 0,1,2,3 months Itch score by visual analog scale,Safety 1,2,3 months Adverse event reporting,Microbial alteration 0,3 months The alpha-diversity, beta-diversity and relative abundance of microbiota,Efficacy 0,1,2 months Local Psoriasis Severity Index | — |
Countries
Thailand
Contacts
Public ContactKrit Pongpirul
Chulalongkorn univesity
Outcome results
None listed