Overweight and obese participants who BMI more than 23.0 kg/m2. High intensity interval training, Asparagus root extract supplementation, Biomarker, Cardiovascular, Obese
Conditions
Interventions
Participants in the control group will be asked to maintain their daily physical activity and dietary intake for 12 weeks. ,Participants in the HIIT group will be asked to perform home-based exercise
No Intervention No treatment,Experimental Procedure/Surgery,Experimental Dietary Supplement,Experimental Other
Control,High intensity interval training (HIIT) ,Asparagus root extract supplementation (ARE),HIIT combined ARE
Sponsors
Burapha University
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1) Male or female and age range 18 to 30 years 2) Body mass index more than 23 kilogram per m2 3) Exercise less than 75 minutes per week
Exclusion criteria
Exclusion criteria: 1) Daily supplementation with drugs or diets 2) Having food or drug allergy i.e., asparagus 3) Regular smoking (> 30 packs-years) 4) Regular alcohol drinking (>1 cup/day) 5) Having drugs or diseases of cardiovascular, respiratory, liver, renal, endocrine, musculoskeletal, infectious, cancer, neurological, or psychiatric disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunology Baseline and post-intervention Intravenous blood sample for about 10 ml will be collected for analyzing immune function (complete white blood cells count),Inflammatory biomarkers Baseline and post-intervention Intravenous blood sample will be collected for analyzing inflammation (IL-6, TNF-alpha).,Oxidative stress biomarkers Baseline and post-intervention Intravenous blood sample will be collected for analyzing oxidative stress (malondialdehyde, protein carbonyl) | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profile Baseline, post-intervention Intravenous blood sample will be collected for analyzing triglyceride, LDL, HDL, and total cholesterol,Fasting blood glucose and insulin levels Baseline, post-intervention Intravenous blood sample will be collected for analyzing fasting blood glucose and insulin levels,Renal and liver functions Baseline, post-intervention For detect any toxi our supplementation, renal function (Blood urea nitrogen, Creatinine) and liver function (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST)) also analyzed. ,Pulmonary function Baseline, post-intervention Pulmonary function will be measured by standard portable spirometers and will report FEV1/FVC, FEV1%, TV, ERV, IRV, IC, MIP, MEP, Chest expansions (upper chest, middle chest, lower chest),Physical fitness Baseline, during, post-intervention A progressive incremental exercise test to volitional fatigue on a motorized treadmill will be performed to determine peak oxygen consumption (VO2peak). ,Vital sign Baseline, during, post-intervention HR, blood pressure (BP), respiratory rate (RR), and partial oxygen saturation (SpO2) will be measured in the supine position by a bed side monitor ,Physical activity level and dietary intake Baseline, during, post-intervention The Beacke Habitual Physical Activity Questionnaire will be used to determine activity levels. The 24 hrs. dietary recall and Food Frequency Questionnaires will be used to determine dietary intake.,Body composition and anthropometry Baseline, during, post-intervention Body composition (body mass, BMI, muscle mass, %body fat, fat mass, water mass, protein mass, mineral mass, bone mass, and visceral fat level) will be measured by a bioelectrical impedance analyzer. | — |
Countries
Thailand
Contacts
Public ContactTadsawiya Padkao
Burapha university
Outcome results
None listed