people with type 2 diabetes mellitus Allulose d-psicose sweetener type 2 diabetes glucose homeostasis MCP-1
Conditions
Interventions
Patients were instructed to drink one bottle of test drink (allulose) with breakfast and one bottle of test drink (allulose) with dinner for 12 weeks. After a 2-week washout period, all study patients
Experimental Other,Active Comparator Other
allulose,aspartame
Sponsors
the Innovation and Technology Assistance Program (ITAP) of the National Science and Technology Development Agency (NSTDA)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. diagnosis of T2D 2. being treated with metformin monotherapy or lifestyle modification 3. a glycated hemoglobin (HbA1c) of <8% 4. not having consumed artificial sweetener for at least 2 weeks
Exclusion criteria
Exclusion criteria: 1. chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <60 ml/min/m2) 2. aminotransferase >3 times the upper limit of normal range 3. severe illness 4. phenylke-tonuria 5. pregnant or breastfeeding 6. taking medication that affects glycemic con-trol (e.g., steroid, estrogen, androgen)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glucose homeostasis at 12 weeks of allulose or aspartame consumption 75-gram oral glucose tolerance test | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c, lipid profile, GLP1, GIP, TNF-alpha, MCP-1 at 12 weeks of allulose or aspartame consumption venous blood sample,body composition at 12 weeks of allulose or aspartame consumption energy X-ray absorptiometry , bioelectrical impedance analysis | — |
Countries
Thailand
Contacts
Public ContactTada Kunavirasut
Faculty of Medicine Siriraj Hospital
Outcome results
None listed