None listed
Conditions
Interventions
Home-based IMT will be performed daily using PowerBreathe device. Total eight week of IMT will be provided. The IMT group will start training at 40% of their initial PImax. The new PImax value will be
Experimental Other,No Intervention Other,No Intervention No treatment
Inspiratory muscle training (IMT),Control,Healthy subject
Sponsors
Mahidol University, Nakhon Pathom, Thailand
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: COPD patients 1) COPD stage mild to very severe defined by GOLD 2021 guideline 2) Aged between 40-80 years 3) No exacerbation within 1 month prior to the study 4) No change in pharmacological treatment within 1 month prior to the study 5) Good ability to communicate and follow instruction ;Healthy subjects 1) aged between 55-80 years 2) normal chest x-ray 3) normal spirometry
Exclusion criteria
Exclusion criteria: COPD patients 1) Pneumothorax 2) A collapsed lung due to a traumatic injury or lung disease 3) Large bullae on chest radiograph 4) History of rib fracture 5) History of recent lung surgery within 6 months 6) Other lung disease that affect on pulmonary function such as asthma, pulmonary fibrosis, pneumonia from COVID-19 7) Progressive neurological or neuromuscular disorders 8) Cardiac arrhythmias 9) Alcoholism 10) Major depression or anxiety disorders 11) Participate in Cardiopulmonary rehabilitation ;Healthy subjects 1) Cardiac arrhythmias 2) Diabetes mellitus 3) Lung diseases 4) Neurological disorders 5) Cancer 6) Uncontrolled hypertension 7) Alcoholism 8) Current smoker 9) Mental disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate variability (HRV) Baseline (COPD and healthy subjects) and 8-week (Only COPD group) ECG monitor ,30:15 ratio Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Ewing test (Heart rate response to standing),Valsalva ratio Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Ewing test (Heart rate response to Valsalva),Max - Min HR Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Ewing test (Heart rate response to deep breathing),SBP change Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Ewing test (Blood pressure response to standing),Max DBP rise Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Ewing test (Blood pressure response to Handgrip exercise),Baroreflex sensitivity Baseline (COPD and healthy subjects) and 8-week (Only COPD group) ECG monitor and blood pressure,Blood pressure variability (BPV) Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Blood pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| Spirometry Baseline (COPD and healthy subjects) and 8-week (Only COPD group) Pulmonary function test,Lung volume Baseline and after 8-week (Only COPD group) Pulmonary function test,6-minute walk distance Baseline (COPD and healthy subjects) and 8-week (Only COPD group) 6-minute walk test,Health status Baseline, 4th week, and after 8-week (Only COPD group) COPD Assessment Test and Clinical COPD Questionnaire,Depression and anxiety Baseline and after 8-week (Only COPD group) Thai Hospital anxiety and depression scale,Dyspnea assessed by mMRC Baseline, 4 week, and after 8-week (Only COPD group) mMRC,Dyspnea assessed by BDI-TDI Baseline for BDI and after 8-week for TDI (Only COPD group) BDI-TDI,Physical activity Baseline and after 8-week (Only COPD group) Thai International Physical Activity Questionnaire,Inspiratory muscle strength in IMT group PImax: Baseline, every week of IMT, and after 8-week (Only COPD group) PImax,Inspiratory muscle strength in control group Baseline and after 8-week (Only COPD group) PImax,Expiratory muscle strength in both groups Baseline and after 8-week (Only COPD group) PEmax,Inspiratory muscle endurance Baseline and after 8-week (Only COPD group) Constant load testing,Respiratory resistance and reactance Baseline and after 8-week (Only COPD group) Impulse oscillometry system (IOS) technique,Gas exchange Baseline and after 8-week (Only COPD group) The diffusing capacity of lung for carbon monoxide (DLCO) | — |
Countries
Thailand
Contacts
Public ContactPairoj Suraprapapich
Mahidol University
Outcome results
None listed