female patients undergoing breast surgery Breast surgery Post operative nausea and vomiting Postoperative pain score Blood glucose Sedation score
Conditions
Interventions
Dexamethasone IV was given as a '
syringe no. 1 '
after induction of anesthesia in dose of 4 mg .
Midazolam 0.04 mg/kg (max 2 mg ) dilute up to 2 mL (1mg/mL) IV was given as a '
syringe no. 2 '
just 30 min before the operation was done.
ondansetron is the open-label drug which given in the same dose in both arms ,Dexamethasone IV was given as a '
after induction of anesthesia in dose of 8 mg .
Normal saline 2 mL IV was given as a '
just 30 min before the operation was done.
ondansetron is the open-label drug which given in the same dose in both arms
Active Comparator Drug,Active Comparator Drug
dexamethasone+ ondansetron+midazolam (DOM),dexamethasone+ ondansetron (DO)
Sponsors
Faculty of Medicine, Chulalongkorn university
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female age 18-65 years old , 2.ASA physical status I-III, 3. BMI 18 - 40 kg/m2
Exclusion criteria
Exclusion criteria: 1. Patient's refusal ,2. Allergic or contraindicate to drug in this trial ,3. Chronic opioid use ( >3 mo) , 4.Chronic benzodiazepine use , 5.Antipsychotic use, 6.previous anticancer chemotherapy within 1 month, 6. Pregnancy ,7.OSA patient ,8. Poor controlled DM (HbA1C>9) , 9. Hx receiving antiemetic within 24 hr
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post operative nausea and vomiting 24 hours incidence of post operative nausea and vomiting | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of postoperative nausea-vomiting at 0 hr ,within 0-2, 2-6, 6-12 , 12-24 hours PONV score,Requirement of rescue antiemetic within 24 hours patient requirement for additional antiemetic drug,Satisfaction for relieving postoperative nausea/vomiting 24 hours postoperative Likert scale 1-5,Pain score at 0 hour , within 0-2 , 2-6, 6-12, 12-24 hours VAS for pain score,Duration of PACU stay Time from admit to discharge from PACU Time from admit to discharge from PACU,Sore throat at 0 hr ,within 0-2, 2-6, 6-12 , 12-24 hours patient were asked if they had sore throat,Sedation score 0 , 30 min , 60 min in PACU observer's assessment of alertness/sedation,Time to eye opening time from discontinuing inhalation to eye opening time from discontinuing inhalation to eye opening,Time to extubation time from discontinuing inhalation to extubation time from discontinuing inhalation to extubation,Blood glucose level preop and at PACU POCT glucose | — |
Countries
Thailand
Contacts
Public ContactKullaporn Mingvoramethakul
Faculty of medicine , Chulalongkorn university
Outcome results
None listed