Effect of Combined Vitamin C and Thiamine Therapy on Myocardial and Inflammatory Markers in Cardiac Surgery: A Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220430005

Enrollment

Registered

2022-04-30

Start date

2022-10-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group vitamin C and NSS will be administered in the dose of 1000 mg of vitamin C dissolved in 50 mL of normal saline and normal saline will receive equivalent fluid volume and intravenous drip within

Active Comparator Drug,Active Comparator Drug

vitamin C only,combine vitamin C and B1

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Scheduled for elective non-emergent valve repair or replacement 2. Aged 18 years or older 3. Left ventricular ejection fraction > 35% 4. No known coagulopathy prior to surgery

Exclusion criteria

Exclusion criteria: Administration of vitamin C or thiamine within 7 days before surgery; Known allergies to vitamin C or thiamine; Indications for thiamine administration (such as chronic alcohol use); Participation in multiple simultaneous research studies; Autoimmune diseases or ongoing immunosuppressive therapy; History of renal calculi and risk of iron overload disorders (e.g., thalassemia and hemochromatosis); Preoperative creatinine clearance < 40 mL/min or serum creatinine > 1.8 mg/dL; Known bleeding disorders or current anticoagulant therapy; Active infection, malignancy, or tumor; History of atrial fibrillation; Pregnancy; Mechanical ventilation or vasopressor/inotropic use on the day of surgery.

Design outcomes

Primary

Measure	Time frame
1.To evaluate effect on inflammatory biomarker (C-reactive protein, C-RP) between group combined vitamin C & B1 and group vitamin C only. pre-op, immediate post-op, post-op day 1 plasma level of C-reactive protein	—

Secondary

Measure	Time frame
evaluate hemodynamic parameters; systolic blood pressure, diastolic blood pressure and mean arterial pressure since before induction to postoperatively period between group before induction of anesthesia though postoperative day 1 systolic blood pressure, diastolic blood pressure, mean arterial blood pressure,evaluate percentage of left ventricular ejection fraction (LVEF) change from preoperative time to 24 hours after surgery before induction of anesthesia, and 24 hours postoperatively left ventricular ejection fraction by SIMPSON's BIPLANE METHOD	—

Measure

Time frame

evaluate hemodynamic parameters; systolic blood pressure, diastolic blood pressure and mean arterial pressure since before induction to postoperatively period between group before induction of anesthesia though postoperative day 1 systolic blood pressure, diastolic blood pressure, mean arterial blood pressure,evaluate percentage of left ventricular ejection fraction (LVEF) change from preoperative time to 24 hours after surgery before induction of anesthesia, and 24 hours postoperatively left ventricular ejection fraction by SIMPSON's BIPLANE METHOD

—

Countries

Thailand

Contacts

Public ContactMantana Saetang

Anesthesiology department, Faculty of Medicine, Prince of Songkla University

stmantana@gmail.com0817597232

Outcome results