Effect of a single low dose preoperative Erythropoietin administration on increasing hemoglobin level in patient undergoing Orthognathic surgery

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220429008

Enrollment

Registered

2022-04-29

Start date

2022-04-11

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Women patients with preoperative mild anemia (hemoglobin level 10-12 g/dL) undergoing Orthognathic surgery Erythropoietin, Hemoglobin, Orthognathic surgery, Iron supplement, Anemia

Interventions

Iron supplement with ferrous fumarate 200 mg 3 times a day for 4 weeks and a single low dose preoperative Erythropoietin (250IU/kg) administration 2 weeks before Orthognathic surgery. ,Iron supplement

Experimental Drug,Placebo Comparator Drug

Group A ,Group B

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Women patients undergoing Orthognathic surgery 2. Patients age over 18 years 3. Mild anemic women with Hb concentration 10-12 g/dL 4. Serum ferritin 35 to 100 ng/mL 5. Healthy patients with ASA class 1-2 6. Body weight 40 to 80 kg

Exclusion criteria

Exclusion criteria: 1. Uncontrolled hypertension 2. Seizures 3. Cardiovascular disease e.g. Stoke, Myocardial infarction 4. Current treatment with NSAIDs, antiplatelet and anticoagulants 5. History of thromboembolism event 6. Anemic conditions contraindicated to Erythropoietin and iron supplement administration e.g. Thalassemia trait, Aplastic anemia, Megaloblastic anemia 7. Current or previous treatment with Erythropoietin or iron supplement and blood transfusion within the last 30 days 8. Abnormal menstruation 9. Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Hemoglobin level The day before surgery Complete blood count	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactSurapong Vongvatcharanon

Prince of Songkla University

surapong.v@psu.ac.th0818215091

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026