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Efficacy and safety of wrist ankle acupuncture combined with oxycodone hydrochloride in the treatment of hepatocellular carcinoma with moderate and severe cancer pain: A protocol of a randomized, single-blind, placebo-controlled clinical trial

Efficacy and safety of wrist ankle acupuncture combined with oxycodone hydrochloride in the treatment of hepatocellular carcinoma with moderate and severe cancer pain: A protocol of a randomized, single-blind, placebo-controlled clinical trial

Status
Unknown
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20220427002
Enrollment
45
Registered
2022-04-27
Start date
2022-05-19
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer pain is one of the most principal clinical symptoms in patients with advanced hepatocellular carcinoma (HCC), which seriously affects the quality of life of patients. How to effectively control cancer pain and reduce adverse drug reactions is the focus of clinical research. Wrist-ankle acupuncture (WAA) is reliable in the treatment of cancer pain, but there are few high-quality and effective follow-up clinical studies on WAA in the treatment of moderate and severe cancer pain in HCC. wri

Interventions

Observation group and control group were given three steps analgesic program. Details are as follows, the use of opioids will be based on the WHO 3-tiered cancer pain ladder. Patients with moderate an
Experimental Other
wrist ankle acupuncture

Sponsors

Zhilin Zhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1 .Patients who are in accordance with the diagnosis of HCC . 2. Aged: 18 to 75 years old, stable and conscious. 3. Patients who have moderate and severe pain, and the 11-point numerical rating scale 4. Patients whose expected survival is over 6 months. (5). Patients who have strong compliance and have signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who are accompanied by infectious diseases, diseases of blood system 2. Patients who have history of acupuncture syncope 3. Women in pregnancy or lactation 4. Patients who have pain associated with causes other than HCC 5. Complicated with other acute symptoms. 6. Skin ulceration at the needling site.

Design outcomes

Primary

MeasureTime frame
11-point numerical rating scale (NRS) 7 days Pain will be measured from 0 to 10, with 0 being no pain and 10 being severe pain.—

Secondary

MeasureTime frame
Effective rate 7 days effective rate complete response number partial response number effective number total number—

Countries

China

Contacts

Public ContactYong Mei

Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of science and technology

drmeiyong@126.com13871077546

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026