Surgeon-administered genicular nerve blocks versus Standard periarticular infiltration for postoperative analgesia in total knee arthroplasty: a randomized non-inferiority trial

Targeted-low-volume versus High-volume local infiltration analgesia for postoperative analgesia after total knee arthroplasty: A randomized non-inferiority trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220406001

Enrollment

140

Registered

2022-04-06

Start date

2022-04-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis going on total knee arthroplasty Knee arthroplasty Local infiltration analgesia Postoperative pain

Interventions

Surgeon administered genicular nerve block were performed intraoperatively by injecting of 0.5% bupivacaine 10 ml combined with adrenaline 0.2 mg, Ketolorac 30 mg, and normal saline up to 40 ml accord

s tubercle (recurrent fibular nerve) and lateral tibia joint line (inferior lateral genicular nerve) : 10 ml Continuous adductor canal block under ultrasound guidance is performed postoperatively by

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Surgeon administered genicular nerve blocks,High-volume local infiltration analgesia

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients scheduled for total knee arthroplasty at King Chulalongkorn Memorial Hospital ASA class 1 to 3 Body mass index (BMI )between 18 to 40 kg/m2

Exclusion criteria

Exclusion criteria: 1. refuse to participate this study 2. unable to cooperate or cognitive impairment 3. allergy to any drug in this study 4. contraindication to neuraxial anesthesia 5. contraindication to NSAIDs Ketorolac and Celebrex 6. chronic opioids use or diagnosed of neuropathic pain 7. unable to performed Time up and go test 8. undergo bilateral knee arthroplasty in the same operation

Design outcomes

Primary

Measure	Time frame
Dynamic pain score during postoperative 12 hours 12 hours Numerical rating scale,Resting pain score during postoperative 12 hours 12 hours Numerical rating scale	—

Secondary

Measure	Time frame
pain score at rest and during movement Postoperative at 0, 4, 8, 12, 24, 36, 48 hours Numerical rating scale,postoperative opioid consumption Postoperative at 12, 24, 48 hours Milligram of Morphine Consumption,Quadriceps Strength 0 and 90 degrees Preoperative, Postoperative 0, 1, 2 Days Maximum voluntary isometric contraction,Timed up and go test Preoperative, Postoperative 1, 2 Days Rehabilitation after surgery,Postoperative Complication Postoperative 0, 1, 2, 3 Days Postoperative Nausea Vomiting, Dizziness, Fall, Sleep disturbance,Length of stay Postoperative to discharge out of hospital Hours,Motor Function of Tibial Nerve Postoperative 6 hours and until did not differ with non-operative leg Plantar Flexion of ankle,Motor Function of Common Peroneal Nerve Postoperative 6 hours and until did not differ with non-operative leg Dorsiflexion of ankle,Patient satisfaction Postoperative day 2 Satisfactory score (1-10),Knee society knee score Preoperative, postoperative 1,2 days score	—

Measure

Time frame

pain score at rest and during movement Postoperative at 0, 4, 8, 12, 24, 36, 48 hours Numerical rating scale,postoperative opioid consumption Postoperative at 12, 24, 48 hours Milligram of Morphine Consumption,Quadriceps Strength 0 and 90 degrees Preoperative, Postoperative 0, 1, 2 Days Maximum voluntary isometric contraction,Timed up and go test Preoperative, Postoperative 1, 2 Days Rehabilitation after surgery,Postoperative Complication Postoperative 0, 1, 2, 3 Days Postoperative Nausea Vomiting, Dizziness, Fall, Sleep disturbance,Length of stay Postoperative to discharge out of hospital Hours,Motor Function of Tibial Nerve Postoperative 6 hours and until did not differ with non-operative leg Plantar Flexion of ankle,Motor Function of Common Peroneal Nerve Postoperative 6 hours and until did not differ with non-operative leg Dorsiflexion of ankle,Patient satisfaction Postoperative day 2 Satisfactory score (1-10),Knee society knee score Preoperative, postoperative 1,2 days score

—

Countries

Thailand

Contacts

Public ContactWannida Kertkiatkachorn

King Chulalongkorn Memorial Hospital

earnearnedearned@gmail.com66954672333

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026