Timing of Intubation Affects Outcomes in Critically Ill COVID-19 Patients

Comparison of outcomes of early vs late or non-intubation strategy in critically ill COVID-19 patients: ambidirectional cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20220328006

Enrollment

108

Registered

2022-03-28

Start date

2021-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically ill COVID-19 patients

Interventions

Intubate within 72 hours after hospital admission,Intubate after 72 hours (late intubation group, LI group) after hospital admission or noninvasive oxygenation strategies including high flow nasal can

Treatment,Treatment

Early intubation group (EI group),Non-early intubation intubation (NEI group)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: COVID-19 infected patients who admitted in COVID-19 ICUs in King Chulalongkorn Memorial Hospital between 1 April 2021 to 31 December 2021 Age equal and more than 18 years old Confirmed COVID-19 infection by RT-PCR from nasopharyngeal swab COVID-19 infected patients who intubation or noninvasive oxygenation strategies

Exclusion criteria

Exclusion criteria: Patients who didn't confirm SAR-CoV-2 PCR or false positive

Design outcomes

Primary

Measure	Time frame
ICU-free day at 30-day after ICU admission Mann-Whitney U test or unpaired T test	—

Secondary

Measure	Time frame
Ventilator-free days at 30 days after ICU admission Mann-Whitney U test or unpaired T test,30-day all-cause mortality at 30 days after hospital admission Chi square test,Secondary bacterial infection since admission until discharge Chi square test,Hospital length of stay since admission Mann Whitney U test or unpaired T test,Time to ICU discharge since ICU admission until 30 days Cox proportional hazard model,Survival rate since ICU admission until 30 days Cox proportional hazard model	—

Measure

Time frame

Ventilator-free days at 30 days after ICU admission Mann-Whitney U test or unpaired T test,30-day all-cause mortality at 30 days after hospital admission Chi square test,Secondary bacterial infection since admission until discharge Chi square test,Hospital length of stay since admission Mann Whitney U test or unpaired T test,Time to ICU discharge since ICU admission until 30 days Cox proportional hazard model,Survival rate since ICU admission until 30 days Cox proportional hazard model

—

Countries

Thailand

Contacts

Public ContactGamonmas Ekkapat

Faculty of Medicine, Chulalongkorn University

gamonmas@yahoo.com0894950088

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026