Preventive or screening RP jelly drink in healthy human volunteers with hyperlipidemia Hyperlipidemia, Oxidative stress, blood lipid profile, inflammation, Passiflora edulis, Hibiscus Sabdariffa
Conditions
Interventions
Jelly drink containing polyphenols-rich roselle calyces extract and passion fruit juice plus pulp concentrate (RP jelly drink),jelly drink without polyphenols-rich roselle calyces extract and passion
Experimental Other,Experimental Other
RP jelly drink ,Placebo
Sponsors
Thailand Institute of Scientific and Technological Research
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: All participants were required to be aged 35 to 60 years with moderate high levels of total cholesterol (more than 200 mg/dL) and/or triglycerides (more than 150 mg/dL) and/or LDL cholesterol (more than 100 mg/dL) and/or HDL cholesterol (less than 40 mg/dL), and could not be using lipid-lowering drugs
Exclusion criteria
Exclusion criteria: Body mass index more than 35 kg/m2, Smokers, Athletes with high physical activity more than 3,000 kcal/day), Diabetes, Multiple allergies, Gastrointestinal disease, Cancer, Central nervous system or Psychiatric disorders, Traumatic injury and having been treated with supplement or any other drugs which were potentially able to affect the lipid metabolism in the previous 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profiles At baseline or before the intervention, at 4 and 8 weeks after the intervention. Blood samples were collected intravenously by a registered nurse and determined biochemical results including blood glucose, TG, TC, HDL-C and LDL-C. | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative Stress Status including Malondialdehyde and glutathione level At baseline or before the intervention, at 4 and 8 weeks after the intervention. Spectrophotometry with enzyme activity,Inflammation Parameters including interleukin 6, 10 and TNF alpha At baseline or before the intervention, at 4 and 8 weeks after the intervention. Enzyme linked immunosorbent assay kit ,A key chemokine of atherosclerotic lesion (MCP 1 expression) At baseline or before the intervention, at 4 and 8 weeks after the intervention Enzyme linked immunosorbent assay kit,Body mass index (BMI) At baseline or before the intervention, at 4 and 8 weeks after the intervention Electronic scale ,Blood pressure At baseline or before the intervention, at 4 and 8 weeks after the intervention. Omron blood pressure monitor | — |
Countries
Thailand
Contacts
Public ContactJurairat Khongrum
Chiang Mai University
Outcome results
None listed