Acetaminophen overdose acetaminophen overdose acetylcysteine adverse effect efficacy
Conditions
Interventions
NAC 100 mg/kg + D5W 200 mL IV drip in 2 hrs then NAC 200 mg/kg + D5W 1000 mL IV drip in 10 hrs
Lab 2 hr before completion the second bag
continue NAC if needed (ALT rising, INR is greater than 1.3,
Active Comparator Drug,Active Comparator Drug
SNAP IV N-acetylcysteine protocol ,Standard IV N-acetylcysteine protocol
Sponsors
Faculty of Medicine, Khon Kaen University
Eligibility
Sex/Gender
All
Age
12 Years to 100 Years
Inclusion criteria
Inclusion criteria: all of these items 1. participant's age 12 years old or older, 2. participant who ingested paracetamol more than 7.5 g or 200 mg/kg or more in any type of acute, staggered, or repeated supratherapeutic ingestion
Exclusion criteria
Exclusion criteria: participants meet at least one item One or more of these items 1) Participant whose initial ALT level is 1000 IU/L or greater 2) Participant who developed liver failure at the initial ED visit 3) Participant who received any routes of NAC from other hospitals before arrival 4) Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy 2 weeks after completion of IV NAC percent of AIHTX | — |
Secondary
| Measure | Time frame |
|---|---|
| serious adverse effect of IV NAC at the end of IV NAC percent of anaphylactoid reactions ,adverse effect at the end of IV NAC rate of severe nausea and vomiting | — |
Countries
Thailand
Contacts
Public ContactThapanawong Mitsungnern
Khon Kaen University
Outcome results
None listed