Nuclear Nutrition Techniques and Clinical Outcomes for Childhood Cancer in Malaysia: A Prospective Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20220323003

Enrollment

181

Registered

2022-03-23

Start date

2022-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anthropometry, body composition, dietary intake, physical activity, energy expenditure, quality of life and clinical outcomes in paediatric cancer patients undergoing treatment and after treatment Anthropometry Body composition Physical activity Energy expenditure Quality of life Clinical outcomes Chemotherapy Cancer Paediatric Children

Interventions

Paediatric leukaemia survivor from previous patients who participated in a doctoral thesis project conducted from the year 2009 to 2011 (Tan et al. 2013a

Tan et al. 2013b), as well as paediatric leukaemia survivors not involved in the doctoral study, who were previously diagnosed with ALL or AML at Hospital Tunku Azizah (HTA), Hospital Kuala Lumpur dur

amp

Roslee, R. 2013a. Physical activity of pediatric patients with acute leukemia undergoing induction or consolidation chemotherapy. Leukemia Research 37(1): 14-20. Tan, S., Poh, B. K., Nadrah, M., Janna

Ismail, M. 2013b. Nutritional status and dietary intake of children with acute leukemia during induction or consolidation chemotherapy. Journal of Human Nutrition and Dietetics 26: 23-33.,Paediatric c

Prevention,Prevention

Paediatric leukaemia survivor (Part I study),Newly diagnosed paediatric cancer patients (Part II)

Eligibility

Sex/Gender

All

Age

2 Years to No maximum

Inclusion criteria

Inclusion criteria: Part I study will recruit a total of 61 paediatric leukaemia survivor from previous patients who participated in a doctoral thesis project conducted from the year 2009 to 2011 (Tan et al. 2013a; Tan et al. 2013b) as well as paediatric leukaemia survivors not involved in the doctoral study, who were previously diagnosed with ALL or AML at Hospital Tunku Azizah (HTA), Hospital Kuala Lumpur during childhood or adolescence and will have their follow-up visits. Part II study will recruit new patients who are diagnosed with paediatric cancer aged 2.00 to 15.99 years and survive more than 3 months post-diagnosis and have sufficient general condition (Lansky score with at least 50 for patients aged below 16 years) (Lansky et al. 1987). References: Tan, S. Y., Poh, B. K., Chong, H. X., Ismail, M. N., Rahman, J., Zarina, A. L., Juraida, A. R. E., Tahir, A., Ruzita, A. T. and Roslee, R. 2013a. Physical activity of pediatric patients with acute leukemia undergoing induction or consolidation chemotherapy. Leukemia Research 37(1): 14-20. Tan, S., Poh, B. K., Nadrah, M., Jannah, N., Rahman, J. and Ismail, M. 2013b. Nutritional status and dietary intake of children with acute leukemia during induction or consolidation chemotherapy. Journal of Human Nutrition and Dietetics 26: 23-33. Lansky, S. B., List, M. A., Lansky, L. L., Ritter-Sterr, C. and Miller, D. R. 1987. The measurement of performance in childhood cancer patients. Cancer 60(7): 1651-1656.

Exclusion criteria

Exclusion criteria: 1. Patients who require a transplant of bone marrow 2. Concurrent illness, such as diabetes, HIV, TB, hormonal problems, and thyroid disease 3. Children with Down syndrome, neurological developmental disabilities before diagnosis that caused patients cannot cooperate in this study 4. Experiencing any form of fever or sepsis

Design outcomes

Primary

Measure	Time frame
Body composition At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Bioelectrical impedance analysis ,Body composition At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Deuterium dilution technique,Total energy expenditure At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months after the first diagnosis. Doubly-labelled water technique,Dietary intake At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. 3-day dietary record ,Physical activity At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Accelerometer,Quality of life At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Pediatric Quality of Life Inventory version 4.0 ,Clinical measures At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Medical record,Physical activity At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Physical activity questionnaire	—

Measure

Time frame

Body composition At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Bioelectrical impedance analysis ,Body composition At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Deuterium dilution technique,Total energy expenditure At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months after the first diagnosis. Doubly-labelled water technique,Dietary intake At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. 3-day dietary record ,Physical activity At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Accelerometer,Quality of life At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Pediatric Quality of Life Inventory version 4.0 ,Clinical measures At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Medical record,Physical activity At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Physical activity questionnaire

—

Secondary

Measure	Time frame
Body weight At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Digital weighing scale ,Standing height At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Stadiometer,Mid-upper arm circumference, waist circumference, hip circumference At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Lufkin tape ,Skinfold thickness (biceps, triceps, subscapular, iliac crest) At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Harpenden skinfold caliper ,Resting metabolic rate At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months after the first diagnosis. Indirect calorimetry ,Sleep At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Children's sleep habits questionnaire ,Handgrip strength At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Digital Hand Dynamometer ,Aerobic capacity and endurance At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Six-minute walk test ,Nutrition beliefs and practices At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Semi-structured interview ,Symptom screening At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the	—

Measure

Time frame

Body weight At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Digital weighing scale ,Standing height At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Stadiometer,Mid-upper arm circumference, waist circumference, hip circumference At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Lufkin tape ,Skinfold thickness (biceps, triceps, subscapular, iliac crest) At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Harpenden skinfold caliper ,Resting metabolic rate At diagnosis, before heading into second, third and fourth courses of chemotherapy, as well as 12 months after the first diagnosis. Indirect calorimetry ,Sleep At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Children's sleep habits questionnaire ,Handgrip strength At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Digital Hand Dynamometer ,Aerobic capacity and endurance At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Six-minute walk test ,Nutrition beliefs and practices At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the first diagnosis. Semi-structured interview ,Symptom screening At diagnosis, before heading into second and fourth courses of chemotherapy, as well as 12 months, 24 months and 36 months after the

—

Countries

Malaysia

Contacts

Public ContactBee Koon Poh

National University of Malaysia

pbkoon@ukm.edu.my60392898035

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026