A Randomized Controlled Trial Comparing Intraperitoneal Low Molecular Weight Heparin and Unfractionated Heparin in Peritoneal Dialysis Related Peritonitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220318003

Enrollment

Registered

2022-03-18

Start date

2021-05-13

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peritoneal dialysis peritonitis Intraperitoneal enoxaparin, Ultrafiltration (UF), Peritoneal solute transport rate (PSTR)

Interventions

IP enoxaparin 4000 units once daily,IP heparin 500 units per liter every cycle

Active Comparator Drug,Active Comparator Drug

IP enoxaparin,IP heparin

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age more than 18 years 2. PD patient with peritonitis

Exclusion criteria

Exclusion criteria: 1. Previous peritonitis within 1 month 2. History of recent bleeding in 1 month 3. current use of low molecular weight anticoagulants, 4. drug allergy.

Design outcomes

Primary

Measure	Time frame
Ultrafiltration At day 7, 14, 30, 60 Milliliter	—

Secondary

Measure	Time frame
To compare peritoneal solute transfer rate(PSTR) before and after intervention Complete antibiotics treatment PET,To compare technical failure at 1 month and 2 months after treatment Day 14, 30, 60 (Technical failure defined as shift mode, death or remove catheter ),To compare the changes of interleukin-6 in dialysis fluids and blood before and after treatment Before and after Complete antibiotics treatment Pg per dl,Adverse effect Day 14, 30, 60 Gi bleeding, death	—

Measure

Time frame

To compare peritoneal solute transfer rate(PSTR) before and after intervention Complete antibiotics treatment PET,To compare technical failure at 1 month and 2 months after treatment Day 14, 30, 60 (Technical failure defined as shift mode, death or remove catheter ),To compare the changes of interleukin-6 in dialysis fluids and blood before and after treatment Before and after Complete antibiotics treatment Pg per dl,Adverse effect Day 14, 30, 60 Gi bleeding, death

—

Countries

Thailand

Contacts

Public ContactDavid Jiravijitkul

els1008@hotmail.com0957673262

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026