neck skin laxity Anesthesia, Chili, Lidocaine, Nociceptive pain, Prilocaine, TRPV1 receptor
Conditions
Interventions
applied capsaicin gel plus topical anesthesia 10 grams 30 minutes prior to microfocused ultrasound treatment,applied topical anesthesia 10 grams 30 minutes prior to microfocused ultrasound treatment
Experimental Drug,Active Comparator Drug
capsaicin gel plus topical anesthesia,topical anesthesia monotherapy
Sponsors
Division of Dermatology, Department of medicine, Faculty of Medicine, Ramathibodi hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Healthy subjects older than 18-year-old with neck skin laxity
Exclusion criteria
Exclusion criteria: The exclusion criteria included pregnancy or active breastfeeding, active skin diseases as well as history of surgery at the experimental sites within 6 months, metal implantation at the experimental sites, abnormal facial/neck sensation, or known allergy to local anesthetics or capsaicin-containing gel. At the time of recruitment, each participant was given a brief explanation of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score after removing anesthetic option (T1), immediately after 4.5 mm transducer (T2a), immediately after 3.0 mm transducer (T2b), and overall pain experience (T3) visual analogue scale | — |
Secondary
| Measure | Time frame |
|---|---|
| redness duration after wiped off the cream time,side effect after complete the procedure participants | — |
Countries
Thailand
Contacts
Public ContactVasanop Vachiramon
Faculty of Medicine, Ramathibodi hospital
Outcome results
None listed