Effects of curcumin extract on transfusion-dependent thalassemia

Effects of curcumin extract, AntioxTM , as an adjuvant therapy for transfusion-dependent thalassemia on oxidative stress, iron overload, hypercoagulability and inflammation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220223004

Enrollment

Registered

2022-02-23

Start date

2022-04-07

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

transfusion-dependent thalassemia transfusion-dependent thalassemia

Interventions

The participants receiving standard treatment concurrently with AntioxTM at the dosage of 500 mg per day in the first phase for 24 weeks, withdrawal for 12 weeks and then starting the second phase wit

Experimental Drug,Experimental Drug

Group AB,Group BA

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: (1) Transfusion-dependent homozygous beta-thalassemia or beta-thalassemia/Hb E (2) Hemoglobin concentration 5-9 g/dl (3) Serum ferritin level > 1000 ng/ml

Exclusion criteria

Exclusion criteria: (1) Lactation or pregnancy (2) ALT, AST > 3 times of the upper limit of normal, Creatinine > 2 mg/dl

Design outcomes

Primary

Measure	Time frame
Iron parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Automated chemistry analyzer/Colorimetric method,Inflammatory parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Particle enhanced immunoturbidimetry/Multiplex cytokine assay,Oxidative stress parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Thiobarbituric acid assay/Colorimetric assay,D-dimer Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Two-step enzyme immunoassay sandwich method	—

Measure

Time frame

Iron parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Automated chemistry analyzer/Colorimetric method,Inflammatory parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Particle enhanced immunoturbidimetry/Multiplex cytokine assay,Oxidative stress parameters Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Thiobarbituric acid assay/Colorimetric assay,D-dimer Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Two-step enzyme immunoassay sandwich method

—

Secondary

Measure	Time frame
Complete blood count Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Automated blood cell analyzer ,Liver and renal function tests Total 7 time points : (1) Baseline, (2) Week 12th, (3) Week 24th, (4) Week 36th, (5) Week 48th, (6) Week 60th, and (7) Week 72th of the study Automated chemistry analyzer	—

Countries

Thailand

Contacts

Public ContactPatarabutr Masaratana

Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand

patarabutr.mas@mahidol.ac.th6624197581

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026