Effect of Mecobalamin on functional outcome of the complex regional pain syndrome type I of foot and ankle , Randomized double blinded controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220221002

Enrollment

Registered

2022-02-21

Start date

2022-02-22

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patient was diagnosed complex regional pain syndrome type I of foot and ankle 18-70 year old. CRPS type I in foot and ankle .

Interventions

at the First OPD visit patient were separate in two group by randomization and prescribe all of following and mecobalamin Tramadol 50 mg 1 tab prn for severe pain q 8 hr 20 tabs Parace

Thai traditional medicine Thammasat university.

Experimental Drug,Placebo Comparator Other

Mecobalamin group,placebo group

Eligibility

Sex/Gender

All

Age

17 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.acute CRPS type I in foot and ankle <symptoms less than 3 month> 2. aged 18-70 year old 3. volunteer , fully conscious ,well to cooperate questionnaire

Exclusion criteria

Exclusion criteria: 1. allergy to Mecobalamin and pregabalin 2. Neuropathy condition such as DM with target organ damage, leprosy, Celebrovascular disease . 3.Pregnancy. 4. current use of vitamin B component drug .

Design outcomes

Primary

Measure	Time frame
functional outcome pre-treatment,1month,3month,6month,12month 1. Short Form Health Survey (SF-36) (Thai version) 2. Foot and Ankle Ability Measure (FAAM) score (Thai version)	—

Secondary

Measure	Time frame
Visual analog scale,Dosage and duration of Pregabalin used pre-treatment,1month,3month,6month,12month Visual analog scale,Dosage and duration of Pregabalin used	—

Countries

Thailand

Contacts

Public ContactMarut Arunakul

Department of Orthopedics, Thammasat university

kai892@hotmail.com0818199455

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026