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Efficacy and safety of combination treatment of fractional carbon dioxide laser and acellular dermal matrix in the treatment of acne scars: A split-face, randomized controlled trial

Efficacy and safety of combination treatment of fractional carbon dioxide laser and acellular dermal matrix in the treatment of acne scar

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20220217008
Enrollment
30
Registered
2022-02-17
Start date
2020-08-17
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne scars Acne scars

Interventions

Fractional CO2 laser was used to treat both sides of the patient&#039
s face. After that, a mixture of cross-link acellular dermal matrix and normal saline (175 mg in NSS 1 ml) was applied to one split-face, which was subsequently covered with silicone gel for one week.
s face. After that, one side was treated with petroleum gel twice a day for 1 week.
Acellular dermal matrix and Fractional carbon dioxide laser,Fractional carbon dioxide laser only

Sponsors

Department of Dermatology, Faculty of Medicine Siriraj Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Moderate acne scar grading from global acne scar grading system both side of the dace for 3 months 2. Fitzpatrick skin type 3-5

Exclusion criteria

Exclusion criteria: 1. photosensitive dermatoses, Skin malignancy, keloid, immunocomporomised host, dermatitis or infeaction at treatment area 2. regular smoking 3. Pregnancy and lactating woman first 3 months 4. Cannot come back for follow up 5. AHA, retinoic acid or topical agents for acne scar within 6 months 6. Laser, RF within 3 months 7. Systemic steroid, immunosuppressive agents within 6 months 8. Oral isotretinoin within 12 months 9. Cannot sign her/his name on inform consent sheet 10. allergic to acellular dermal matrix / silicone (Megaheal)

Design outcomes

Primary

MeasureTime frame
scar depression volume at 1 months, 3 months and 6 months after intervention Antera 3D camera

Secondary

MeasureTime frame
safety at 1 months, 3 months and 6 months after intervention history tajing and physical examination

Countries

Thailand

Contacts

Public ContactRungsima Wanitphakdeedecha

Faculty of Medicine Siriraj Hospital, Mahidol University

rungsima.wan@mahidol.ac.th0816406300

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026