Clinical use of gamma-H2AX in predicting treatment response in locally advanced rectal cancer patients treated with preoperative chemoradiation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20220209008

Enrollment

Registered

2022-02-09

Start date

2020-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Locally advanced rectal cancer patients Gamma-H2AX preoperative concurrent chemoradiation rectal cancer tumor response tumor regression grading

Interventions

Patients with first diagnosis of locally advanced rectal cancer

Diagnostic

Locally advanced rectal cancer

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: - Age 18 - 80 years old - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Biopsy proven adenocarcinoma of rectum - Clinical stage T3 or T4 or regional lymph node positive, who is indicated for preoperative CCRT - Basic Laboratories within normal limit (CBC, BUN/Cr, LFT) and serum creatinine clearance at least 30 - Signing of informed consent

Exclusion criteria

Exclusion criteria: - Patients with previous history of radiation - Recurrent rectal cancer - Receive pretreatment systemic chemotherapy - Uncontrolled medical conditions or connective tissue disease - Treatment with palliative treatment aim

Design outcomes

Primary

Measure	Time frame
Gamma-H2AX Baseline Gamma-H2AX activation level,Gamma-H2AX 24 hours after 1st clinical fractionation Gamma-H2AX activation level,Gamma-H2AX mid-treatment Gamma-H2AX activation level,Gamma-H2AX End of treatment Gamma-H2AX activation level,Gamma-H2AX 6 weeks after completion Gamma-H2AX activation level	—

Secondary

Measure	Time frame
Toxicity Weekly Toxicity	—

Countries

Thailand

Contacts

Public ContactPiyapasara Toapichattrakul

Division of Radiation Oncology, Faculty of Medicine, Chiang Mai University

earnnpick@gmail.com0899515923

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026