postoperative pain after open inguinal hernia repair dexmedetomidine, inguinal hernia repair, ilioinguinal/iliohypogastric nerve block, tumescent anesthesia, pain
Conditions
Interventions
local dexmedetomidine with local bupivacaine,IV dexmedetomidine with local bupivacaine,local bupivacaine, IV placebo
Experimental Drug,Experimental Drug,Experimental Drug
DexLA,DexIV,Control
Sponsors
Navamindradhiraj University Research Fund
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: An adult patients age 18 - 75 years uncomplicated inguinal hernia fully inform consent ASA classification I-III Non pregnant woman Non immunocompromised disease hosts including HIV, taking immunosuppressive drug, has ascites, morbid obesity
Exclusion criteria
Exclusion criteria: Emergency operation Subject cannot communicate with outcome assessor such as deafness, mental problem. Subject who is in bed ridden status. Subject who have preexisting chronic pain or daily consumption greater than 20 mg of oral morphine equivalent Subject who have either baseline heart rate less than 50 bpm, or atrioventricular block on 12-lead ECG Subject who have history of study drug allergy including dexmedetomidine, bupivacaine, propofol, fentanyl, tramadol, celecoxib, paracetamol and sulfa. Subject who have glomerular filtration rate less than or equal 30 mL per minute Subject who have history of gastrointestinal bleeding, coronary artery bypass graft surgery, and myocardial infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS at 6 hours postoperatively at 6 hours VAS | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of surgery finish operation begin surgical incision to finish the operation,time to ambulation discharge from PACU, 3h, 6h, 12h, 24h postoperatively time ,time to home readiness at PACU admission, PACU discharge, 3h, 6h, 12h, 24h postoperatively modified PADSS,hospital length of stay hospital discharge time admit to discharge,PACU length of stay PACU discharge time in PACU,rate of conversion to general anesthesia intraoperative convert to general anesthesia,IV opioid consumption intraoperative, postoperative IV opioid consumption,time to first dose of postoperative opioid in first 24 hours postoperative time,, VAS at rest and on exertion at PACU admission, PACU discharge, 3rd hour, 6th hour, 12th hour, 24th hour VAS,intraoperative hypotension intraoperative blood pressure,intraoperative bradycardia intraoperative HR,femoral nerve palsy first 24 hours postoperatively manual muscle test,urinary retention first 24 hours postoperatively on foley catherter,nausea/vomiting at PACU, 0-6h, 6-12h, 12-24h postoperative nausea/vomiting,pruritus at PACU, 0-6h, 6-12h, 12-24h postoperative pruritus,hematoma at PACU, 0-6h, 6-12h, 12-24h postoperative hematoma | — |
Countries
Thailand
Contacts
Public ContactPruchwilai Nuchpramool
Vajira hospital, Navamindradhiraj university
Outcome results
None listed