Effect of platelet rich plasma of voice outcomes following phonosurgery for benign lesions vocal fold polyp platelet rich plasma effect outcome phonosurgery
Conditions
Interventions
The standard surgical procedure is suspension micro laryngeal surgery (MLS) using cold steel instruments, under microscopic guidance. After hemostasis, 1ml of PRP to be injected in the upper surface o
Experimental Procedure/Surgery,Experimental Procedure/Surgery
PRP,NON-PRP
Sponsors
Iuliu Hatieganu University of Medicine and Pharmacy
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Unilateral benign vocal fold pathology requiring phonosurgical intervention. The lesion size should not account for more than 50% of the true vocal fold length. Patients between 18-75 years of age considered eligible.
Exclusion criteria
Exclusion criteria: Exclusion criteria: upper respiratory infections two weeks prior to surgery, clinical signs of malignancy or recurrent respiratory papillomatosis, uncertainty of clinical diagnosis, bilateral vocal fold pathology, prior phonosurgical intervention, voluminous unilateral lesion occupying the whole length of the vocal fold, sulcus vocalis, severe cardiovascular and pulmonary pathology after preanesthesia evaluation, patients not fit for surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| voice quality three days and 3 weeks following the procedure Two way ANOVA- comparing fundamental frequency, jitter and shimmer before and after the procedure. Measured by voice analysis softwre | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjectivbe voice assesmenet before the procedure and three weeks after the procedure Mean and standard deviation for each group. VHI 30 questionnaire comparing values before and three weeks after the procedure (0-no subjective voice complaint, 120 maximum score)) | — |
Countries
Romania
Contacts
Public ContactUjvary Laszlo Peter
Iuliu Hatieganu Universily of Medicine and Pharmacy
Outcome results
None listed