The effects of respiratory muscle training on neural respiratory drive and cardiac autonomic function in patients submitted to open-heart surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220127003

Enrollment

Registered

2022-01-27

Start date

2018-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary dysfunction and impaired cardiac vagal modulation are reported after cardiac surgery whereas respiratory muscle training (RMT) has also been proved as a complementary technique to improve respiratory muscle and cardiac autonomic properties. However, the efficacy of RMT technique has not been investigated in patients who had undergone open-heart surgery. Respiratory muscle training, Neural respiratory drive, Cardiac autonomic function, Heart rate variability, Open-heart

Interventions

Participants allocated to the experimental group were performed cardiac rehabilitation programs (same as the control group) and completed with respiratory muscle training (RMT). The RMT protocol was i

D Biomedical, Thailand) with daily loads adjustment at 30% of maximal respiratory pressures. The RMT training contained three sets of 10 repetitions with 2- and 10-minutes rest between sets and loadin

Experimental Other,No Intervention Other

Experimental group,Control group

Eligibility

Sex/Gender

All

Age

36 Years to 65 Years

Inclusion criteria

Inclusion criteria: All the participants aged 35 to 65 years who were admitted to Thammasat University Hospital, Thailand, for coronary artery bypass graft or heart-valve surgery

Exclusion criteria

Exclusion criteria: Participants were excluded if they had a history of prior cardiac surgery, heart failure, uncontrolled blood pressure, uncontrolled diabetes mellitus, pulmonary diseases, neurological disorders, body mass index greater than 35 kg/m2, or required mechanical ventilator support for more than 24 hours postoperatively

Design outcomes

Primary

Measure	Time frame
Neural respiratory drive (NRD) sEMGpara was measured at rest while patients perform normal tidal breathing for one minute (sEMGpara tidal) and collected during execute a maximal static inhalation (sEMGpara max) NRD was acquired by measuring surface parasternal intercostal electromyogram (sEMGpara) using a wireless EMG system (TeleMyo 2400T G2, Noraxon USA Inc., Scottsdale, AZ, USA)	—

Secondary

Measure	Time frame
Heart rate variability (HRV) HRV was measured while performing a 1-minute paced deep breathing maneuver HRV was recorded using a V800 Polar monitor (Polar Electro Ltd., Kempele, Finland) and analyzed by Kubios HRV software v. 3.0.2	—

Countries

Thailand

Contacts

Public ContactKaran Pongpanit

Thammasat University

karan.p@allied.tu.ac.th029869213

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026