Comparison between ampicillin-sulbactam and cefoxitin as prophylaxis antibiotics in patients undergoing pancreaticoduodenectomy after preoperative biliary drainage

Comparison between ampicillin-sulbactam and cefoxitin as prophylaxis antibiotics in patients undergoing pancreaticoduodenectomy after preoperative biliary drainage : A Randomized controlled Trial

Status

Unknown

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20220120001

Enrollment

140

Registered

2022-01-20

Start date

2020-07-19

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical site infection in patients undergone pancreaticoduodenectomy with preoperative biliary drainage . Surgical site infection , SSI , biliary drainage

Interventions

Standard preoperative antibiotic and postoperative antibiotic Perioperative phase

2g intravenous every 2 hour Post operative for 24 hour

1g intravenous every 6 hour,Standard Preoperative antibiotic and postoperative antibiotic Perioperative phase

3g intravenous every 2 hour Post operative for 24 hour

3g intravenous every 6 hour

Active Comparator Drug,Active Comparator Drug

Cefoxitin,Ampicillin-sulbactam

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age more than 18 2.Patients underwent Pancreaticoduodenectomy

Exclusion criteria

Exclusion criteria: 1.patients that not underwent preoperative biliary drainage. 2.Patients with history of drug allergy

Design outcomes

Primary

Measure	Time frame
Surgical site infection At 12 months after end of intervention Wound infection rate	—

Secondary

Measure	Time frame
Length of hospital stay Within first admission or Re-admitted within 30 days Length of hospital stay (days)	—

Countries

Thailand

Contacts

Public ContactRuj Rujchasenee

Faculty of Medicine Ramathibodi Hospital

Peem.ruj@gmail.com6622011315

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026