Epidermal, dermal, or mixed type melasma on both cheeks in Asians Efficacy, safety, tranexamic acid and hyaluronic acid loaded microneedle patch, oral tranexamic acid, melasma
Conditions
Interventions
Tranexamic acid and hyaluronic acid loaded microneedle patch 5 mg/cm2 twice weekly on both cheeks ,Oral tranexamic acid 250 mg twice daily
Tranexamic acid and hyaluronic acid loaded microneedle patch,Oral tranexamic acid
Sponsors
Ethics and Research Standardization Section, Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years 2. Healthy 3. Both cheeks with any types of melasma
Exclusion criteria
Exclusion criteria: 1. Pregnancy, or breastfeeding 2. On oral contraceptive pill within 1 year 3. Previous treatment with laser or light within 6 months 4. Previous treatment with topical antipigmented agents within 1 month 5. Other dermatoligic lesions on cheeks such as infection, or any inflammations 6. History of venous thrombosis, abnormal bleeding, or any coagulopaties 7. Allergic to tranexamic acid or hyaluronic acid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Melasma at 24 weeks after end of the intervention modified Melasma Area Severity Index (mMASI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Melanin at 24 weeks after end of the intervention Melanin Index | — |
Countries
Thailand
Contacts
Public ContactChantaluck Muennarong
Skin Center Srinakharinwirot University
Outcome results
None listed