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A comparison of intravenous pulse methylprednisolone and dexamethasone on idiopathic sudden sensorineural hearing loss : A double-blind randomized controlled trial

A comparison of intravenous pulse methylprednisolone and dexamethasone on idiopathic sudden sensorineural hearing loss : A double-blind randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20211224004
Enrollment
30
Registered
2021-12-24
Start date
2021-11-25
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

idiopathic sudden sensorineural hearing loss Idiopathic sudden sensorineural hearing loss, steroid, intravenous pulse methylprednisolone, intravenous dexamethasone

Interventions

intravenous pulse methylprednisolone 250 mg q 12 hr x3 days,intravenous dexamethasone 4 mg q 8 hr x 3 days
Experimental Drug,Experimental Drug
intravenous pulse methylprednisolone,intravenous dexamethasone

Sponsors

Sirinkarn Sookdee
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Unilatearal sudden sensorineural hearing loss <= 14days 2.Audiogram shows Pure Tone Average :PTA > 30 bD at least 3 frequency

Exclusion criteria

Exclusion criteria: 1. no stroke/brain tumor 2.no history of ear/head truama 3. no history of ototoxic drug use 4.no history of loud noise exposure 5. no history of ear infection 6. no history of steroid use within 1 month 7. no history of steroid allergy/ immunocompromised host/ DM 8.no history of GI bleeding 9. no pregnancy or breast feeding

Design outcomes

Primary

MeasureTime frame
Recovery level 3day,10day,17day Audiogram

Secondary

MeasureTime frame
Side effect 3day,10day,17day Questionaire

Countries

Thailand

Contacts

Public ContactSirinkarn Sookdee

Faculty of Medicine Burapha University

s.sirinkarn@gmail.com66945422651

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026