Acute CPPD attack CPPD attack
Conditions
Interventions
Oral prednisolone 5 mg twice daily,Oral prednisolone 15 mg twice daily
Experimental Drug,Active Comparator Drug
Prednisolone 10 mg/day,Prednisolone 30 mg/day
Sponsors
FACULTY OF MEDICINE VAJIRA HOSPITAL
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients presented with an acute CPPD attack, and crystal-proven CPP crystal by arthrocentesis
Exclusion criteria
Exclusion criteria: 1. Secondary cause of CPPD - hemochromatosis - hyperparathyroidism - hypophosphatasia - hypomagnesemia 2. Septic arthritis or Uncontrolled systemic infection 3. DKA or HHS 4. BP >180/110 mmHg 5. Active GI hemorrhage 6. Prior use of colchicine or NSAIDs in past 1 week 7. Neurologic deficit causing decreased pain sensation around the involved joint 8. Intubated 9. Used of corticosteroid due to other indication (such as COPD with acute exacerbation)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to complete resolution 28 days VAS score less than 2, swelling in the index joint (4-point Likert scale; 0), tender in the index joint (4-point Likert scale less than 1) | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to clinical resolution 28 days VAS score,Recurrence rate of acute CPPD attack within 28 days 28 days new inflammation in any other joints | — |
Countries
Thailand
Contacts
Public ContactWuttirak leelasattakul
NMU
Outcome results
None listed