Effect of Appropriate Dose, Spectrum, and Timing of Antibiotics on 28-day Mortality in Patients with Sepsis in the Emergency Department Appropriate antibiotics, timing, dose, spectrum, sepsis, 28-day mortality, emergency department
Conditions
Interventions
1) appropriate time of antibiotics administration (measured as the receipt of the first dose within 60 minutes from the time of triage)
2) appropriate spectrum (in a review of the results of hemoculture or specimen culture, or an antibiotics spectrum covering the suspected source pathogen. Patients with any infection source or negativ
2) inappropriate spectrum (not meeting the above definition)
and 3) inappropriate dose (not meeting the above definition)
Other,Other
an appropriate antibiotics group ,an inappropriate antibiotics group
Sponsors
no
Eligibility
Sex/Gender
All
Age
15 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1) aged >15 years; 2) diagnosed with sepsis according to the ICD-10 or by an attending physician or according to the results of blood culture, body fluid culture, or specimen culture; and 3) patients in the ED in whom the Ramathibodi sepsis protocol had been followed
Exclusion criteria
Exclusion criteria: 1) patients who had received oral antibiotics within the past 7 days, 2) patients with cardiac arrest before arrival in the ED or with a do-not-resuscitate order signed on the day of arrival in the ED; 3) patients with a definite diagnosis unrelated to sepsis; 4) patients who were transferred out of the ED within 24 hours; 5) patients referred in from other hospitals, and 6) patients with missing data in the Ramathibodi Hospital database and emergency medical record.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day mortality day 28 death at day 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality time to disposition from hospital hospital death,28-day ventilator- free days day 28 day alive without ventilator in 28 day,28-day hospital- free days day 28 day alive without hospital in 28 day | — |
Countries
Thailand
Contacts
Public ContactPitsucha Sanguanwit
Mahidol university
Outcome results
None listed