Efficacy and Safety of Microneedle Patch Containing Triamcinolone Acetonide in the Treatment of Inflammatory Acne

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211215006

Enrollment

Registered

2021-12-15

Start date

2021-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory acne inflammatory acne microneedle triamcinolone acetonide

Interventions

Place the microneedle patch with the adhesive side over the acne to be treated and press lightly for 10 seconds then place 2 drops of normal saline on the back of the microneedle patch then gently mas

Experimental Device,Experimental Device,Experimental Device,No Intervention No treatment

700 um microneedle patch containing triamcinolone acetonide,1000 um microneedle patch containing triamcinolone acetonide,700 um microneedle patch without triamcinolone acetonide,Control group (no trea

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Male or female aged more than 18 year-old 2. At least four facial inflammatory papules or pustules 3. Willingness to volunteer to participate in the trial and sign the informed consent form

Exclusion criteria

Exclusion criteria: 1. Acne extraction or intralesional steroid injection within 2 weeks 2. Ablative or non-ablative lasers on face within 2 weeks 3. Dermatitis, photodermatitis or skin injection on face 4. Pregnant or lactating women 5. Unable to follow up as required

Design outcomes

Primary

Measure	Time frame
Time to resolution of inflammatory acne At day 2, 3, 7, 14, 28 after treatment Physician grading	—

Secondary

Measure	Time frame
Changing in diameter of inflammatory acne (millimeter) at day 2, 3, 7, 14, 28 after treatment Measure diameter of acne by Vernier caliper, Changing in volume of inflammatory acne (cubic millimeters) at day 2, 3, 7, 14, 28 after treatment Measure volume of acne by antera 3D,Changing in erythema index (A* value) at day 2, 3, 7, 14, 28 after treatment Erythema index by Colorimeter,Changing in melanin index (L* value) at day 2, 3, 7, 14, 28 after treatment Melanin index by Colorimeter,Safety and side effects at day 2, 3, 7, 14, 28 after treatment Patients' reports (irritation, pain, infection, bruising, skin atrophy, hyperpigmentation and hypopigmentation),Patient and physician satisfaction at day 7 after treatment Visual analogue scale,Patient preference at day 7 after treatment Questionnaire	—

Measure

Time frame

Changing in diameter of inflammatory acne (millimeter) at day 2, 3, 7, 14, 28 after treatment Measure diameter of acne by Vernier caliper, Changing in volume of inflammatory acne (cubic millimeters) at day 2, 3, 7, 14, 28 after treatment Measure volume of acne by antera 3D,Changing in erythema index (A* value) at day 2, 3, 7, 14, 28 after treatment Erythema index by Colorimeter,Changing in melanin index (L* value) at day 2, 3, 7, 14, 28 after treatment Melanin index by Colorimeter,Safety and side effects at day 2, 3, 7, 14, 28 after treatment Patients' reports (irritation, pain, infection, bruising, skin atrophy, hyperpigmentation and hypopigmentation),Patient and physician satisfaction at day 7 after treatment Visual analogue scale,Patient preference at day 7 after treatment Questionnaire

—

Countries

Thailand

Contacts

Public ContactSoraya Thantaviriya

Srinakharinwirot University

soraya_ploy@hotmail.com0818345217

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026