Healthy Thai female subjects aged between 35-60 years Anti-wrinkle
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Women between 35 and 60 years of age 2. All skin types (normal, dry, oily and combination skin) 3. Having clearly visible wrinkle at eye corner (crow's feet) or forehead 4. Having experience using a counter brand facial skin care 5. Willing to participate in the study after being informed objective, methodology, risk and benefit of the study 6. Be able to read, communicate and write Thai language 7. Willing to stop using commercially available skin smoothing, moisturizer, and anti-wrinkle products 8. Willing to sign the consent form after being explained and provided all information related to potential impact of the study (volunteers can ask any information about this study except the confidential business information of product)
Exclusion criteria
Exclusion criteria: 1. Having underlying disease and continuous taking medicine 2. Having history of eczema or psoriasis within 6 months before enrollment in this study 3. Having history of major operation within 1 year 4. Having history of skin cancer within 1 year 5. Having wound and scar around the study-evaluating face area 6. Applying any medicines for treatment facial skin diseases 7. Having history of using steroid, antibiotic, non-steroidal anti-inflammatory or antihistamine within 3 days before enrollment in this study 8. Having history of using topical medicine on face within 3 weeks before enrollment in this study 9. Having allergic history to mangosteen, pomegranate, tomato, or carrot 10. Having allergic history to any ingredient in commercially available anti-wrinkle products 11. Pregnancy or lactation 12. Having history of smoking at least 1 cigarette/day 13. Having history of consuming at least 1 glass/day or 250 milliliters 14. Using or having history of substance abuse 15. Having history of participating in other clinical study within 3 months before enrollment in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Facial roughness and wrinkles 8 weeks measuring by Primos lite,Skin moisture 8 weeks measuring by Corneometer,Skin elasticity 8 weeks Measuring by Cutometer | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Cosmetics and natural products research center, Pharmaceutical sciences, Naresuan university