Patients with mild to severe post acne erythema according to Clinician erythema assessment criteria Post acne erythema, Oxymetazoline hydrochloride
Conditions
Interventions
According to the randomization, subjects will be instructed to apply a maximum of 10 drops of topical 0.05% Oxymetazoline hydrochloride on the left or right side of their face. Subjects are advised to
Active Comparator Drug,Placebo Comparator No treatment
0.05% Oxymetazoline hydrochloride ,Normal saline solution
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Subjects aged 18-45 years diagnosed by a dermatologist for mild to severe post acne erythema according to Clinician erythema assessment criteria. 2. Subjects who are informed in detail about the research study and express their interests in participation. 3. Subjects with redness scores from the VISIA differed by no more than 10% on both sides of the face.
Exclusion criteria
Exclusion criteria: 1. Subjects with a history of rosacea or other active dermatitis on the treatment site. 2. Previously known allergic reaction to oxymetazoline 3. Subjects with a past medical history of hypertension, asthma, cardiovascular disease, cerebrovascular disease, vascular disease, close angle glaucoma, hypotension, or postural hypotension. 4. Female subjects who are currently in pregnancy or breastfeeding 5. Subjects who had previously treated post acne erythema with topical medications such as azelaic acid, or other facial procedures such as lasers, injections, or any chemical treatment within three months before study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of post acne erythema leision week 0, 2,4, 8, 12 PAE leision counts | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythema score week 0, 2,4, 8, 12 Visia image analysis for erythema score evaluation,Erythema score week 0, 2,4, 8, 12 Chroma meter CR-400,Erythema Score week 0, 2,4, 8, 12 Clinician erythema assessment scale,Adverse effect week 0, 2,4, 8, 12 number of events,Satisfaction score after treatment week 0, 2,4, 8, 12 Subject's assessment by visual analogue scales(VAS) | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Division of Dermatology, Faculty of Medicine, Chulalongkorn university
Outcome results
None listed