Acne scar Acne scar, topical insulin, microneedle fractional radiofrequency
Conditions
Interventions
Microneedle fractional radiofrequency and then topical insulin apply at randomized side,Microneedle fractional radiofrequency and then topical NSS at another side
Experimental Procedure/Surgery,Placebo Comparator Procedure/Surgery
Microneedle fractional radiofrequency with topical insulin,Microneedle fractional radiofrequency alone
Sponsors
Division of Dermatology, Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. No serious underlying conditions 2. Symmetrical facial acne scar 3. Agree to participate and signed informed consent form
Exclusion criteria
Exclusion criteria: 1. History of infection at facial area 2. Uncontrolled acne vulgaris 3. History of keloid scar or hypertrophic scar 4. Immunocompromised host 5. History of dermatological malignancy 6. History of herpes infection 7. History of using vitamin A derivatives within 3 months 8. History of laser treatment within 3 months 9. History of chemical peeling within 3 months 10. Underlying diabetes mellitus, connective tissue diseases, and photodermatoses 11. Allergic to insulin and topical anesthesic drugs 12. Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scar volume Every visit Percentage changes in scar volume | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective assessment by two blinded dermatologists Every visit ECCA Grading scale,Patient's evaluation of the improvement score 3 months after the end of the intervention Visual analogue scale,Patient's satisfaction evaluation 3 months after the end of the intervention Visual analogue scale,Side effects 0, 1,2,3,4 and 6 months after procedure Investigator's evaluation | — |
Countries
Thailand
Contacts
Public ContactTeerapong Ratananukrom
Division of Dermatology, Ramathibodi Hospital, Mahidol University
Outcome results
None listed