Prevalence of helicobacter pylori is 17-55%. Ten to twenty percents of H.pylori infection were failed to treatment with first line regimen. Refractory H.pylori infection defined as H.pylori infection which failed to treatment with at least 2 regimens. There was not standard regimen for H.pylori infection. Refractory Helicobacter pylori, Helicobacter pylori, Resistant Helicobacter pylori
Conditions
Interventions
Vonoprazan 20 mg twice daily (40mg/day)
Sitafloxacin 100 mg twice daily (200mg/day)
Amoxycillin 1000 mg twice daily (2000 mg/day)
Duration : 7 days
Experimental Drug
VAS rigimens
Sponsors
Routine to Research Unit, Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patient with refractory H.pylori defined as failed to at least 2 H.pylori eradication regimens
Exclusion criteria
Exclusion criteria: - Patient with history to sitafloxacin, amoxycillin or vonoprazan allergy - Pregnancy - Patient with immunodeficiency, decompensated cirrhosis and end stage renal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy (eradication rate of VAS regimen) 4 weeks after intervention Percentage of successful eradication | — |
Secondary
| Measure | Time frame |
|---|---|
| Characteristic of Refractory H.pyloi infection patients at the begin of study Age, sex, antibiotic susceptibility of H.pylori, CYP2C19 polymorphism | — |
Countries
Thailand
Contacts
Public ContactTanawat Geeratragool
Division of gastroenterology and hepatology, Department of internal medicine, Faculty of medicine Siriraj hospital
Outcome results
None listed