Healthy conditions Tuna oil working memory emotional stresses aging process perimenopausal menopausal women
Conditions
Interventions
Subjects are received the placebo product which has the same color and smells look like Tuna oil plus DHA beverage.,Subjects are received Tuna oil plus DHA beverage containing Tuna oil 2,432.43 mg per
Placebo,Tuna oil plus DHA beverage containing Tuna oil 2,432.43 mg per day,Tuna oil plus DHA beverage containing Tuna oil 5,837.84 mg per day
Sponsors
Program Management Unit Competitiveness (PMUC)
Thai Union Group PCL.
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Healthy perimenopausal and postmenopausal women (<5 years menstruation cessation) who live in Northeastern Thailand 2. Aged between 45-60 years old 3. Body Mass Index (BMI) between 18-23 kg/m2
Exclusion criteria
Exclusion criteria: 1. Volunteers who have been diagnosed with one of the following; diabetes mellitus, cardiovascular diseases, liver disease, kidney disease, respiratory diseases, autoimmune disease, hematological disorder, cancer, and head injury 2. Volunteers who have been Hysterectomy and/or Oophorectomy 3. Volunteers who use hormone or any drug that effect on Hypothalamic Pituitary Gonadal axis and nervous system three months before the test 4. Volunteers who require supplements or any drugs that affect the nervous system by order of the doctor before the test 5. Volunteers who have taken any antibiotics medication or paracetamol one month before the test 6. Athlete or volunteers who have a regular exercise more than 3 times per week 7. Smoking more than 10 pieces per day 8. Drinking alcohol more than 5 times per day 9. Volunteers who participate in other projects 10. Volunteers who have taken any antiplatelet or anticoagulants drugs 11. Fish oil allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P300 8 weeks Event related evoked potentials (ERPs) | — |
Secondary
| Measure | Time frame |
|---|---|
| Working memory 8 weeks Computerized batteries test,Oxidative stress markers including Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT), and Glutathione peroxidase (GSH-Px) 8 weeks Laboratory,Total phenolic compound and Omega-3 8 weeks Laboratory,Inflammatory markers including C-Reactive protein (CRP), Interleukin-6, and TNF-alpha 8 weeks ELISA method,Glutathione reductase 1, Glyoxalase 1, and Endothelial nitric oxide synthase (eNOS) 8 weeks ELISA method,Aging parameters (telomere length, sirtuin, CD23, homocysteine) 8 weeks Laboratory,Body Mass Index (BMI) and Body Composition 8 weeks Equipment,Short chain fatty acids and microbiota 8 weeks Laboratory,Thai version of the Pittsburgh Sleep Quality Index 8 weeks Questionnaire,Depression Anxiety Stress Scales 8 weeks Questionnaire,The changes of hematological and clinical chemistry parameters 8 weeks laboratory | — |
Countries
Thailand
Contacts
Public ContactJintanaporn Wattanathorn
Khon Kaen University
Outcome results
None listed