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The Efficacy of Intra-articular Tranexamic acid combined with Epinephrine in Arthroscopic ACL reconstruction: Double-blinded randomized controlled trial

The Efficacy of Intra-articular Tranexamic acid combined with Epinephrine in Arthroscopic ACL reconstruction: Double-blinded randomized controlled trial

Status
Unknown
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20211124002
Enrollment
124
Registered
2021-11-24
Start date
2021-06-21
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACL injury patient ACL injury Tranexamic acid

Interventions

Intra-articular injection of Tranexamic acid 15 mg/kg diluted with NSS up to 50 ml ,Intra-articular injection of Tranexamic acid 15 mg/kg and 0.25 mg of epinephrine diluted with NSS up to 50 ml
Experimental Drug,Active Comparator Drug
Tranexamic acid ,Tranexamic acid and Epinephrine

Sponsors

Nakornping Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patient who underwent primary single-bundle arthroscopic ACL reconstruction using a hamstring autograft with or without meniscal surgeries in Nakornping hospital from 1st June 2021 to 31st May 2023

Exclusion criteria

Exclusion criteria: Use of other grafts Revision ACL reconstruction Concomitant knee cartilage or collateral ligament surgeries History of knee surgery on the affected knee Concomitant fracture Coagulation or bleeding disorders Preoperative anticoagulation treatment History of tranexamic acid or epinephrine allergy

Design outcomes

Primary

MeasureTime frame
Drain output volume 24 hours postoperative ml

Secondary

MeasureTime frame
Different of hemoglobin level pre- and postoperative at 24 hours g/dL,Range of motion pre- and postoperative at 2, 6, 12 weeks Degrees,Mid patellar circumference pre- and postoperative at 2, 6, 12 weeks cm,Lysholm score pre- and postoperative at 2, 6, 12 weeks Points,International Knee Documentation Committee score pre- and postoperative at 2, 6, 12 weeks Points,Hemarthrosis grading postoperative day 3 Grade,Calf circumference postoperative day 3 cm

Countries

Thailand

Contacts

Public ContactChaloemwut Piyaphattachai

Nakornping hospital

earn-mail@hotmail.com0918533105

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026