The difference of extubation time after target-controlled infusion of propofol anesthesia in pediatric patients undergoing long-duration surgery among age groups

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211120003

Enrollment

Registered

2021-11-20

Start date

2021-12-06

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergence time and extubate time after long-duration infusion of propofol in children. Emergence time, extubate time, tci, propofol, pediatric anesthesia

Interventions

Anestheisa with TCI propofol Paedfusor model in long-duration anesthesia (more than 120 minutes) At preoperative area, patients will receive midazolam 0.1 mg/kg IV (maximum 2 mg) for anxiolysis within

Experimental Drug

Anestheisa with TCI propofol Paedfusor model in long-duration anesthesia (more than 120 minutes)

Eligibility

Sex/Gender

All

Age

1 Years to 15 Years

Inclusion criteria

Inclusion criteria: 1. Children aged 1 to 15 years old, 2. Patients with ASA physical status 1 - 3, 3. Patients who schedule for elective surgery with mild to moderate pain for more than or equal to 120 minutes duration, 4. Patients who require general anesthesia with an endotracheal tube and muscle relaxant and expected to extubate after the anesthesia

Exclusion criteria

Exclusion criteria: 1. Patients who weigh less than the 5th percentile or greater than the 95th percentile 2. Patients with severe cardiovascular, neurological, hepatic, or renal impairment 3. Patient with a known allergy to any of the drugs involved in the study such as propofol (and its composition; soybean oil, egg, etc.), midazolam, fentanyl, cis-atracurium, lidocaine and ondansetron 4. Children with lower or upper respiratory tract infection having purulent nasal discharge, fever, or a cough 5. Patients with abnormal lipid or carbohydrate metabolism 6. Patients who being on anticonvulsants or psychiatric medications 7. Patients who require supplemental regional anesthesia or peripheral nerve block for pain control

Design outcomes

Primary

Measure	Time frame
Extubation time immediately after finish operation time (min)	—

Secondary

Measure	Time frame
Hemodynamic profile intraoperative Blood pressure,Percentage of time in targeted BIS intraoperative BIS,Sedation score after emergence in PACU Pediatric Sedation-Agitation Scale (P-SAS) ,Time to ready to discharge in PACU The Modified Aldrete Score,Propofol consumption intraoperative mg,Ce awake intraoperative from TCI device,Ce intubation intraoperative from TCI device	—

Countries

Thailand

Contacts

Public ContactIssada Jindawatthana

Faculty of medicine Siriraj hospital

issada.j@gmail.com66860246432

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026