close contact with TB/MDR-TB patients close contact, tuberculosis, multiple drug resistance tuberculosis, innate immunity, strenuous exercise, macrophage function
Conditions
Interventions
Cycle ergometry at 70-80%HRR, at exercise room 3 days/week for 12 weeks. ,Stretching exercise at home 3 days per week for 12 weeks with normal physical activity.
Experimental Other,Active Comparator Other
Strenous exercise program,Control group
Sponsors
the project TB/MDR-TB research capacity building in low- and middle-income countries in the Southeast Asia under the fund of Fogarty International Center/ National Institute of Health (NIH)
Faculty of Medicine Research Fund
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. People who living with TB/MDR-TB patients for 2 months, will select only one person in the household that meets the inclusion criteria. 2. Tuberculin skin test negative (TST less or equal to 15 mm) 3. Age 20 to 40 year 4. Body weight more than 50 kg 5. Cooperation and can participate at least 2 months of the program 6. No immune deficiency condition and not take an immunosuppressive drug 7. Nonexercise participant, for example, does not work that requires physical exertion or exercise regularly 8. The maximum oxygen consumption (VO2max) less than 40 ml/kg/min 9. Not have precaution of exercise
Exclusion criteria
Exclusion criteria: 1. Chronic pulmonary disease 2. Infectious arthritis 3. Underlying of diabetes mellitus 4. History of HIV+ 5. Use supplement products /food 6. Pregnancy 7. Anemia (Hb less than 7 g/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ability of host macrophages to infect mycobacteria and the level of inflammatory cytokines secretion at 0 and 48 hours after infection The level of cytokine secretions and number of colony forming unit | — |
Secondary
| Measure | Time frame |
|---|---|
| Forced vital capacity (FVC) before and after 12 weeks of the program Will be measured in sitting position on a comfortable chair with a nose clip. Then perform normal inspire and expire for 3 times followed by a maximum expiration after maximum inspiration as rapidly,Forced expiratory in 1 second (FEV1) before and after 12 weeks of the program Will be measured in sitting position on a comfortable chair with a nose clip. Then perform normal inspire and expire 3 times follow by forcefully as possible for at least 6 seconds,Maximum voluntary ventilation (MVV) before and after 12 weeks of the program The participant will use a mouthpiece and wear a nose clip. All of them are instructed to breathe rapidly and deeply for 12 seconds.,The physical fitness test (VO2max) before and after 12 weeks of the program will use the Astrand-Rhyming cycle ergometer test | — |
Countries
Thailand
Contacts
Public ContactSaikaew Chuachan
Faculty of Medicine
Outcome results
None listed