Silver penetration in root carious lesions

Silver ion penetration in root carious lesions treated with thirty eight percent of silver diamine fluoride: in vivo

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211110003

Enrollment

Registered

2021-11-10

Start date

2021-10-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Root carious lesions Root caries Dental caries Cervical caries

Interventions

38% silver diamine fluoride will be applied to a root carious lesion for 1 minute with a microbrush.

Experimental Drug

38% silver diamine fluoride application

Eligibility

Sex/Gender

All

Age

40 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Adults age 40 year old and above 2. Presence of a supragingival root carious lesion 3. No history of pain 4. Tooth may or may not be required extraction

Exclusion criteria

Exclusion criteria: 1. Allergic to silver 2. Extremely deep lesion, exposed pulp 3. Presence of ulcerative gingivitis and stomatitis

Design outcomes

Primary

Measure	Time frame
Microbial profiles 2 weeks Fluorescent signal (cycle)	—

Secondary

Measure	Time frame
Hardness change 2 weeks Yes or No change of hardnesse	—

Countries

Thailand

Contacts

Public ContactSupawadee Naorungroj

Prince of Songkla Unviersity

supawadee.n@psu.ac.th66918269596

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026