The patient was scheduled for an elective procedure under propofol-based total intravenous anesthesia (TIVA) propofol pain
Conditions
Interventions
60 mg of 2% lidocaine 3 mL,Hyoscine N-Butylbromide was diluted with normal saline up to 3 mL
Active Comparator Drug,Active Comparator Drug
2% lidocaine (L group),Hyoscine N-Butylbromide (H group)
Sponsors
Khon kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 60 years old, 2. ASA PS classification 1-2
Exclusion criteria
Exclusion criteria: 1. Allergy to lidocaine and Hyoscine N-butylbromide 2. BMI < 18 or > 25 3. Prescribed other analgesics, antimuscarinic or anti-inflammatory drugs 4. history of chronic pain conditions 5. Difficulty in communication or pain assessment 6. Neurological disease 7. Diabetes Mellitus 8. Contraindication for hyoscine such as untreated glaucoma, gut obstruction, benign prostate hyperplasia with urinary retention, and cardiovascular disease 9. Contraindication for lidocaine such as severe bradycardia, Wolf-Parkinson-White syndrome, and other tachyarrhythmias
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain scores After propofol injection 100-mm visual analog scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of tachycardia 5 minutes after injection of intervention drugs Heart rate more than 20% from baseline,Incidence of hypotension 5 minutes after injection of intervention drug systolic blood pressure below 90 mmHg | — |
Countries
Thailand
Contacts
Public ContactSaranyoo Nonphiaraj
Faculty of Medicine, Khon Kaen University
Outcome results
None listed