A randomized controlled trial comparing intro-operative wound irrigation with normal saline versus aqueous chlorhexidine for surgical site infection prevention

Comparative Efficacy of Intraoperative Wound Irrigation with Aqueous Chlorhexidine versus Normal Saline to Prevent Surgical Site Infections: A Double-blind Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211027010

Enrollment

400

Registered

2021-10-27

Start date

2021-11-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal surgery Wound irrigation Normal saline Aqueous chlorhexidine Surgical site infection Abdominal surgery

Interventions

using normal saline for wound irrigation before skin closure,using aqueous chlorhexidine for wound irrigation before skin closure

Placebo Comparator Drug,Active Comparator Drug

Normal saline,Aqueous chlorhexidine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: -Adult patients who are more than 18 years old. -Abdominal surgery from any incision or gastrointestinal pathology -Clean-contaminated, and contaminated wound Classification. -American Society of Anaesthesiologists (ASA) patient classification < 5.

Exclusion criteria

Exclusion criteria: -Dirty wound classification -Potential second-look operation or planned revisionary surgery -Already participate in the other trials involving abdominal operation. -Not willing to participate

Design outcomes

Primary

Measure	Time frame
Surgical site infection 1 month CDC criteria for SSI	—

Secondary

Measure	Time frame
wound seroma/hematoma/evisceration 2 week Clinical examination	—

Countries

Thailand

Contacts

Public ContactSuphakarn Techapongsatorn

Navamindradhiraj University

suphakarn@nmu.ac.th0891268484

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026