Can thrombin generation assay infer plasma FVIII:C in adult Thai hemophilia A?

Can Thrombin Generation Assay infer plasma FVIII:C in Adult Thai Hemophilia A?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20211027003

Enrollment

Registered

2021-10-27

Start date

2020-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The adult severe hemophilia A patients followed up at Hematology clinic, Siriraj hospital. Hemophilia A, Hemophilia, Thrombin generation assay, FVIII, Inhibitors, Bypassing agents

Interventions

The adult severe hemophilia A patients followed up at Hematology clinic, Siriraj hospital.

Diagnostic

Severe hemophilia A

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Severe hemophilia A 2. Age of more than 18 years 3. Last FVIII transfusion of longer than 72 hours

Exclusion criteria

Exclusion criteria: 1. concomitant antiplatelets and/or anticoagulants used 2. chronic kidney disease stage 4-5 (glomerular filtration rate of less than 30 mL/minute) 3. liver impairment (prothrombin time of longer than 16 seconds)

Design outcomes

Primary

Measure	Time frame
Thrombin generation assay parameters at the day of blood collection calibrated automated thrombography (CAT)	—

Secondary

Measure	Time frame
correlation of TGA parameters and FVIII:C at the day of blood collection calibrated automated thrombography (CAT)	—

Countries

Thailand

Contacts

Public ContactNawapotch Donsakul

Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University

nawapotch@gmail.com0896699633

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026