Benefits of noninvasive continuous positive airway pressure ventilation (NIV-CPAP) for severe blunt chest injuries: A randomized controlled study

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211025006

Enrollment

Registered

2021-10-25

Start date

2017-12-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Several studies have suggested that non-invasive ventilator reduced mortality and intubation rate in respiratory failure. However, the benefits of NIV-CPAP for the management of severe blunt chest trauma are still controversial. Noninvasive ventilator continuous positive airway pressure, blunt chest injury, thoracic trauma severity score

Interventions

the patients were applied with suitable size of face mask. Leakage was checked and the machine was set according to the ventilation protocol. ,Oxygen mask with bag 10 liter per minute were provided.

Experimental Device,Experimental No treatment

noninvasive continuous positive airway pressure ventilation (NIV-CPAP),conventional oxygen therapy

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Between 18 - 65 years old concomitant with blunt chest injury, patent airway in the first seen 2. Trauma thoracic severity score between 5 - 15 points or chest abbreviated injury scale (AIS) more than 3 points

Exclusion criteria

Exclusion criteria: 1. Included moderate to severe hypoxemia (PaO2 < 65 mmHg or SpO2 < 90 % at room air) 2. Required emergency surgery following admission 3. Required endotracheal tube intubation immediately on admission 4. Uncooperative patients 5. Severe mid facial injury which was not suitable for applying the face mask 6. Hypercarbia (PaCO2 > 45 mm Hg) 7. Severe acidosis with pH < 7.2 8. Hemodynamic instability after proper resuscitation 9. Significant co-morbidity (cerebrovascular accident, recent coronary arterial disease, poor control diabetic mellitus, end stage renal disease) 10. Claustrophobic or oronasal mask intolerance 11. Contraindication for epidural analgesia or other analgesic agents

Design outcomes

Primary

Measure	Time frame
the intubation rate at 12 months after end of the intervention Chi square or Fisher exact test	—

Secondary

Measure	Time frame
length of ICU stay at 12 months after end of the intervention t-test and Mann-Whitney U test logistic regression	—

Countries

Thailand

Contacts

Public ContactJatuporn Sirikun

Siriraj hospital, mahidol university

j_sirikun@hotmail.com024197727

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026