Prediction Score for the International Normalized Ratio in Patient with Paracetamol Overdose Ingestion

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20211025005

Enrollment

Registered

2021-10-25

Start date

2021-11-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient with Paracetamol Overdose Ingestion, INR level International Normalized Ratio INR Paracetamol overdose Paracetamol toxicity Acetaminophen overdose Acetaminophen toxicity

Interventions

1.Patients who had ingested acetaminophen more than 150 mg/Kg or 7.5 grams within a single 4-hour period (Acute overdose) 2.Patients who had measured prothrombin time (PT) and INR

Other

Patient with Paracetamol Overdose Ingestion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients who had ingested acetaminophen more than 150 mg/Kg or 7.5 grams within a single 4-hour period (Acute overdose) 2)Patients who had measured prothrombin time (PT) and INR

Exclusion criteria

Exclusion criteria: 1.Coingested substances reported to interfere CYP2E1 eg. SSRI 2.On CYP inducer drug eg.Isoniazid, Rifampin, Anti-convulsant 3.On anticoagulant eg.warfarin 4.Documented of liver disease 5.Advanced cancer 6.Present evident of acetaminophen induced hepatotoxicity while taken blood for INR level eg. AST or ALT more than 1000 unit/liter

Design outcomes

Primary

Measure	Time frame
Predicted INR level First INR lab result at the beginning of study INR level	—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactPraewalan Suwannatrai

Emergency Department, Faculy of Medicine, Chiang Mai University

praewalan.suwan@cmu.ac.th053936722

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026