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Efficacy of drug delivery technique in thoracic epidural block

Comparison of analgesic efficacy between programmed intermittent epidural bolus (PIEB) and continuous epidural infusion (CEI) of patient controlled thoracic epidural analgesia after upper abdominal surgery, a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20211021005
Enrollment
120
Registered
2021-10-21
Start date
2021-10-25
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patient-controlled thoracic epidural analgesia after upper abdominal surgery patient-controlled epidural analgesia, thoracic epidural analgesia, programmed intermittent bolus, abdominal surgery

Interventions

PCEA setting is programmed intermittent epidural bolus (PIEB) with 0.1% bupivacaine with fentanyl 2 microgram/ml, 4 ml every 40 minutes. Participants are allowed for PCEA dose of 3 ml with lockout int
Experimental Other,Active Comparator Other
programmed intermittent epidural bolus (PIEB) ,Continuous epidural infusion (CEI)

Sponsors

Faculty of Medicine, Chulalongkorn University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Scheduled for elective open upper abdominal surgery 2. General anesthesia combined with thoracic epidural anesthesia. 3. Age 18-65 years old 4. American Society of Anesthesiology (ASA) Physical Status class 1-3

Exclusion criteria

Exclusion criteria: 1. Patients who refused to participate in the study. 2. Patients with contraindications and a history of allergy with drugs used in the study. 3. Patients who are contraindicated for epidural analgesia are: 4. Patients with neurologic disorder. 5. Patients with chronic pain 6. Inadequate epidural analgesia after surgery 7. Patients who are unable to use the patient-controlled epidural analgesia

Design outcomes

Primary

MeasureTime frame
Local anesthetic consumption 24 h postoperatively mL

Secondary

MeasureTime frame
Pain intensity every 6h during 60 hours postoperatively Numeric rating scale,Local anesthetic consumption 48 and 60 h postoperatively mL,Hypotension Every 4h during the follow up period Incidence of hypotension,Lower limb weakness Every 12 hour during follow up period Bromage score

Countries

Thailand

Contacts

Public ContactPongkwan Jinaworn

Faculty of medicine, Chulalongkorn Univerity

pongkwan.j@chula.ac.th0933398896

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026