A comparison between 0.3 and 0.5 mcg/kg/h of dexmedetomidine infusion for prevention of intraoperative tachycardia during off-pump coronary artery bypass surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211018003

Enrollment

Registered

2021-10-18

Start date

2021-10-18

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease involve left anterior descending artery OPCAB, off-pump coronary artery bypass surgery, coronary artery disease, dexmedetomidine, tachycardia

Interventions

dexmedetomidine infusion dose 0.3 mcg/kg/h,dexmedetomidine infusion dose 0.5 mcg/kg/h

Active Comparator Drug,Active Comparator Drug

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Operation involves LAD anastomosis, ASA class II-IV, patients taking oral beta blocker within 24 hours before surgery, patients with left ventricular ejection fraction more than 35 percent

Exclusion criteria

Exclusion criteria: malignant arrhythmia, preoperative heart rate less than 50 bpm, preoperative hypotension or unstable hemodynamics, allergic to dexmedetomidine, dexmedetomidine administration within 24 hour before surgery, redo-operation

Design outcomes

Primary

Measure	Time frame
Tachycardia event during LAD anastomosis mean, SD or median, IQR	—

Secondary

Measure	Time frame
hemodynamics preoperative, after A-line placement, after complete loading dexmedetomidine, during sternotomy, during LAD anastomosis, during wound closure, during ICU admission Mean, SD or median, IQR,beta-blocker, inotrope, vasodilator, vasopressor use preoperative, after A-line placement, after complete loading dexmedetomidine, during sternotomy, during LAD anastomosis, during wound closure, during ICU admission number, percentage,IABP use intraoperative number, percentage,amount of blood loss, IV fluid and blood component use intraoperative mean, sd or median, IQR,extubation time postoperative mean, sd or median, IQR,ICU admission time postoperative mean, sd or median, IQR,cardiac enzyme level 24 hour after surgery mean, sd or median, IQR,new onset AF, stroke, acute kidney injury, delirium 24 hour after surgery number, percentage	—

Measure

Time frame

hemodynamics preoperative, after A-line placement, after complete loading dexmedetomidine, during sternotomy, during LAD anastomosis, during wound closure, during ICU admission Mean, SD or median, IQR,beta-blocker, inotrope, vasodilator, vasopressor use preoperative, after A-line placement, after complete loading dexmedetomidine, during sternotomy, during LAD anastomosis, during wound closure, during ICU admission number, percentage,IABP use intraoperative number, percentage,amount of blood loss, IV fluid and blood component use intraoperative mean, sd or median, IQR,extubation time postoperative mean, sd or median, IQR,ICU admission time postoperative mean, sd or median, IQR,cardiac enzyme level 24 hour after surgery mean, sd or median, IQR,new onset AF, stroke, acute kidney injury, delirium 24 hour after surgery number, percentage

—

Countries

Thailand

Contacts

Public ContactAnesthesiology Khon Kaen University

ANESKKU

jidath@kku.ac.th043363060

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026