Patient who undergoes infratentorial craniotomy Infratentorial craniotomy Postoperative nausea vomiting Intravenous anesthesia Inhalation anesthesia
Conditions
Interventions
Maintenance of anesthesia during the operation is total intravenous anesthesia with target controlled infusion (TCI) propofol 4-6 mcg/ml (Schnider model) and fentanyl 0.2-0.5 mcg/kg/hr.,Maintenance of
Experimental Other,Active Comparator Other
Total intravenous anesthesia,Inhalation
Sponsors
Faculty of Medicine, Chulalongkorn university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient who undergoes infratentorial craniotomy 2. The American Society of Anesthesiologists (ASA) Physical Status Classification I-III 3. Expected to extubate after surgery
Exclusion criteria
Exclusion criteria: 1. Patient who refuse to be included in the project. 2. Anesthesia without surgery. 3. Patient who receive combined intravenous anesthesia and inhaled anesthesia. 4. Patient with increased intracranial pressure. 5. Patient with abnormal liver function or chronic alcoholism. 6. Patient who is suspected for malignant hyperthermia 7. Patient with opioid allergy. 8. Patient who receive antiemetic prophylaxis within 24 hours before surgery. 9. Patient with history of chemotherapy within 4 weeks before surgery or radiation within 8 weeks before surgery. 10. Patient who remain intubated after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative nausea/vomitting 24 hours postoperatively PONV scoring | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative nausea/vomitting 0, 0.5,1,2,6,12,48 hours postoperatively PONV scoring,Brain relaxation before dura opening and during surgery Brain relaxation score assessed by surgeon,Antiemetic medication 48 hours post operative Total amount of antiemetic medication patient received,Mean blood pressure, heart rate baseline, intubation, dural opening, every hour during surgery, dural closure, extubation Mean blood pressure, heart rate,Medication for hemodynamic control during the surgery Amount of norepinephrine, labeterol , esmolol,Anesthesia and Surgical time during the operation Time of anesthesia and Surgery,Time to follow command, time to eye opening, time to extubation After stopping the anesthetic agent time after the cessation of the anesthetic agent to time when patient follow command, open their eyes and extubatne | — |
Countries
Thailand
Contacts
Public ContactApisara Wongwaikijphaisant
Department of Anesthesiology, Faculty of Medicine, Chulalongkorn university
Outcome results
None listed