Comparison of nalbuphine versus morphine for the recovery of bowel function

Comparison of nalbuphine versus morphine for the recovery of bowel function in patient underwent colorectal surgery: A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20211012002

Enrollment

Registered

2021-10-12

Start date

2021-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient undergoing elective laparoscopic colonic surgery Enhanced recovery after colon and rectal surgery, ERAS, Nalbuphine, Recovery of bowel function

Interventions

single opioid drug for intraoperative and postoperative analgesia,single opioid drug for intraoperative and postoperative analgesia

Experimental Drug,Active Comparator Drug

Nalbuphine,Morphine

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patient undergoing elective laparoscopic colonic surgery, 2. ASA physical status classification I-III

Exclusion criteria

Exclusion criteria: 1. Allergy to research medications, 2. Inability to communicate pain, 3. Inability to use PCA, 4. Open surgery, 5. Ostomy, 6. Chronic pain more than 3 months or a history of chronic opioid use, 7. Postoperative ICU and remained intubate

Design outcomes

Primary

Measure	Time frame
colonic transit time 5 days after surgery Number of radiopaque markers (Sitz marks) in plain film abdomen	—

Secondary

Measure	Time frame
Numerical pain score at rest at 24h 24 hour after surgery Numerical pain score,Numerical pain score on movement at 24h 24 hour after surgery Numerical pain score,PCA opioid consumption 24 hour after surgery milligrams and morphine equivalent doses,Incidence of post operative ileus within 5 days after surgery defined as 3 episodes of first 24 h after surgery (milligrams and vomiting over 24 hours, cessation of oral diet, or need for nasogastric tube within 5 days after surgery,time to first flatus after surgery hour	—

Measure

Time frame

Numerical pain score at rest at 24h 24 hour after surgery Numerical pain score,Numerical pain score on movement at 24h 24 hour after surgery Numerical pain score,PCA opioid consumption 24 hour after surgery milligrams and morphine equivalent doses,Incidence of post operative ileus within 5 days after surgery defined as 3 episodes of first 24 h after surgery (milligrams and vomiting over 24 hours, cessation of oral diet, or need for nasogastric tube within 5 days after surgery,time to first flatus after surgery hour

—

Countries

Thailand

Contacts

Public ContactMarvin Thepsoparn

Faculty of Medicine Chulalongkorn University

marvin.thep@gmail.com022564000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026