COVID-19 patients with persistent olfactory dysfunction Olfactory dysfunction, COVID-19, Olfactory training, Intranasal corticosteroids
Conditions
Interventions
Mometasone furoate intranasal spray (50 mcg/puff) 2 puff each nostril once in the morning ,Olfactory training
Active Comparator Drug,Placebo Comparator Procedure/Surgery
Intranasal corticosteroids,Olfactory training
Sponsors
Ratchadaphiselsomphot grant
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age > 18 years 2. Asymptomatic-to-moderate COVID-19 (do not need high flow nasal canula or ventilator) 3. Olfactory dysfunction during COVID-19 infection and also having olfactory dysfunction during 8 weeks and 6 months after diagnosis of COVID-19
Exclusion criteria
Exclusion criteria: 1. Olfactory dysfunction prior to COVID-19 2. Clinical of chronic rhinitis or chronic rhinosinusitis 3. Intranasal tumor e.g. hemangioma, inverted papilloma 4. History of nasal or neurological surgery 5. Other current clinical of significant neurological disease 6. Current clinical of psychiatric disorders e.g. major depressive disorder 7. During receiving steroids form other conditions within 2 weeks 8. Pregnant 9. Major visual or auditory problem such as blindness or deafness which limit communication with the instructor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Olfactory identification 12 weeks Olfactory identification score | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public Contacttipyada papassornsiri
King Chulalongkorn memorial hospital
Outcome results
None listed