Morbid obesity Morbid obesity, Bariatric surgery, Nefopam
Conditions
Interventions
Nefopam 80mg in NSS to 500 ml IV drip rate 125 ml/hr in 1 hr before the operation finished then IV drip rate 20 ml/hr for 24 hr.,NSS to 500 ml IV drip rate 125 ml/hr in 1 hr before the operation finis
Active Comparator Drug,Placebo Comparator Drug
Sponsors
Faculty of Medicine Siriraj Hospital Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 yrs 2. Scheduled for laparoscopic bariatric surgery 3. Be able to control Patient-controlled analgesia pump 4. Understand Thai consent received
Exclusion criteria
Exclusion criteria: 1. Contraindicated for Nefopam use 2. Known history of cardiac disease : CAD, CHF, arrhythmia 3. CrCl < 40ml/min 4. Chronic liver disease Child Pugh class B,C 5. Hypersensitivity to nefopam, fentanyl, bupivacaine 6. Chronic opioid user
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nefopam can decrease fentanyl consumption postoperatively in patients undergoing laparoscopic bariatric surgery at 6 hours after operation finished Numeric Rating Scale Score | — |
Secondary
| Measure | Time frame |
|---|---|
| Nefopam can decrease fentanyl consumption at 24 hours postoperatively in patients undergoing laparoscopic bariatric surgery at 24 hours after operation finished Numeric Rating Scale Score | — |
Countries
Thailand
Contacts
Public ContactSamita Pirotesak
Department of Anesthesia, Siriraj hospital
Outcome results
None listed