hypocalcemia hypernatremia metabolic alkalosis cardiac arrhythmia Regional citrate anticoagulants Saline flushing intermittent hemodialysis
Conditions
Interventions
Regional citrate anticoagulant for prevent dialyzer clotting,Saline flushing for prevent dialyzer clotting
Experimental Drug,Experimental Drug
Sponsors
Bhumibol Adulyadej Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Acute setting ; AKI,ESRD Age > 18 yrs Informed consent Undergoing central venous catheters or AVF/AVG, by prescription HD: Low flux dialyzer BFR 200 ml/min Dialyzate Ca 1.75 mEq/L Duration 4 hr
Exclusion criteria
Exclusion criteria: 1.Patients were treated with antiplatelet,oral anticoagulant therapy or other drugs known to affect coagulation within 7 days 2. Acute liver failure 3. DIC 4. Contraindication to systemic anticoagulation: Abnormal plasma total calcium < 7.0 mg/dL Abnormal plasma total magnesium <1.8 mg/dL Abnormal plasma total sodium >145 mg/dL metabolic alkalosis; serum bicarb > 28 mEq/L Known allergy to citrate Documented arrhythmia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dialyzer clots 0,60,120,240 min percent of dialyzer clots | — |
Secondary
| Measure | Time frame |
|---|---|
| hypocalcemia 0,60,120,240 min incidence of hypocalcemia,hypernatremia 0,60,120,240 min incidence of hypernatremia,metabolic alkalosis 0,60,120,240 min incidence of metabolic alkalosis | — |
Countries
Thailand
Contacts
Public ContactTheerapun Boonsayomphu
Bhumibol Adulyadej Hospital
Outcome results
None listed