Efficacy and Adverse Effects of Curcumin in Patient with Hand Osteoarthritis

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210929003

Enrollment

Registered

2021-09-29

Start date

2021-09-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis hands patients presenting with hand pain, stiffness and impaired hand function at Out-Patient Department, Ramathibodi Hospital. curcumin, hand osteoarthritis, hand stiffness, hand pain, tumeric capsule, hand function

Interventions

Patients will recieve curcumin (Tumeric casule 500 mg) 2 tabs three times per days for 12 weeks,Patients will recieve placebo capsule 2 tabs three times per days for 12 weeks

Experimental Drug,Placebo Comparator Drug

Curcumin group,Placebo group

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients ages > 50 years 2. Fulfilling the American College of Rheumatology criteria for hand osteoarthritis 1990 3. At least 1 tender joint 4. Joint pain 30 mm according to a visual analog scale (100 mm) 5. No history of fracture or dislocation in hand 6. Accpeted inform consent

Exclusion criteria

Exclusion criteria: 1. History of hand joint surgery 2. Exclude inflammatory joint arthritis 3. Treatment with oral corticosteroids, intra-articular corticosteroids, or hyaluronic acid injection within the previous 3 months 4. On antiplatelet/anticoagulant/chemotherapy 5. Abnormal sensation and motor of upper extremities 6. Abnormal liver function or liver disease 7. Abnormal renal function 8. Allergy to curcumin or NSIADs

Design outcomes

Primary

Measure	Time frame
Hand pain at rest At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand pain and ten is maximum pain.	—

Secondary

Measure	Time frame
Hand pain at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand pain and ten is maximum pain.,Hand morning stiffness at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand stiffness and ten is maximum hand stiffness.,Hand grip strength At baseline, 12 weeks and 24 weeks Kg,Pinch strength At baseline, 12 weeks and 24 weeks Kg,Hand function At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks DASH,Amount of rescue drug At 4 weeks, 8 weeks, 12 weeks and 24 weeks Number of NSAIDs and Acetaminophen	—

Measure

Time frame

Hand pain at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand pain and ten is maximum pain.,Hand morning stiffness at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand stiffness and ten is maximum hand stiffness.,Hand grip strength At baseline, 12 weeks and 24 weeks Kg,Pinch strength At baseline, 12 weeks and 24 weeks Kg,Hand function At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks DASH,Amount of rescue drug At 4 weeks, 8 weeks, 12 weeks and 24 weeks Number of NSAIDs and Acetaminophen

—

Countries

Thailand

Contacts

Public ContactChawanin Lerspongpaibool

Faculty of Medicine Ramathibodi Hospital, Mahidol University

chawanin@gmail.com0875517770

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026